Female rats display higher methamphetamine-primed reinstatement and c-Fos immunoreactivity than male rats.
Female rats display higher methamphetamine-primed reinstatement and c-Fos immunoreactivity than male rats.
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雌性大鼠表现出较高的甲基苯丙胺引发的恢复和c-Fos免疫反应性比雄性大鼠。
DOI：
10.1016/j.pbb.2020.173089
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发表时间：
2021-03
影响因子：
3.6
通讯作者：
Bevins, Rick A.
中科院分区：
文献类型：
--
作者：
Pittenger, Steven T.;Chou, Shinnyi;Murawski, Nathen J.;Barrett, Scott T.;Loh, Olivia;Duque, Juan F.;Li, Ming;Bevins, Rick A.
甲基苯丙胺（冰毒）依赖的特征通常是持续和慢性复发（即，回到药物使用）。以前的研究表明，女性可能有更大的复发风险。在这项研究中，我们扩展了这一有限的证据，并确定了性别依赖的神经基质与甲基触发的恢复。雄性和雌性Sprague-Dawley大鼠植入颈静脉留置导管。然后训练一半的大鼠自我给药冰毒（0.05 mg/kg/inf）;另一半在21个每日疗程（2 h）期间自我给药盐水。然后给老鼠12次灭绝期。在最后一次消退期后24小时，大鼠接受恢复测试。一半大鼠接受meth-prime（0.3 mg/kg，IP）注射，其余大鼠接受生理盐水注射。这种设计导致每种性别有4个独立的组，允许仔细研究与甲基触发的恢复相关的大脑区域。在恢复期后收获脑，并在多个脑区域中测量c-Fos免疫反应性。甲基触发恢复在两种性别和这种影响是更强大的女性相比，男性。检测到显著的性别差异。女性表现出更大的c-Fos免疫反应性扣带皮层区1，外侧眶额皮质，前边缘皮质，尾壳核，核c-Fos核心和外壳，杏仁核中央核甲基引发恢复。
Methamphetamine (meth) dependence is often characterized by persistent and chronic relapse (i.e., return to drug use). Previous work suggests females may be at greater risk to relapse. In this study, we extended this limited evidence and identified sex-dependent neural substrates related to meth-triggered reinstatement. Male and female Sprague-Dawley rats were implanted with indwelling jugular catheters. Half of the rats were then trained to self-administer meth (0.05 mg/kg/inf); the other half self-administered saline during 21 daily sessions (2 h). Rats were then given 12 extinction sessions. Twenty-four hours after the last extinction session, rats received reinstatement testing. Half of the rats received a meth-prime (0.3 mg/kg, IP) injection and the remaining rats received a saline injection. This design resulted in 4 separate groups for each sex, allowing for careful investigation of brain regions related to meth-triggered reinstatement. Brains were harvested following the reinstatement session and c-Fos immunoreactivity was measured in multiple brain regions. Meth triggered reinstatement in both sexes and this effect was more robust in females compared to males. Significant sex differences were detected. Females showed greater c-Fos immunoreactivity in the cingulate cortex area 1, lateral orbitofrontal cortex, prelimbic cortex, caudate-putamen, nucleus accumbens core and shell, and central nucleus of the amygdala following meth-primed reinstatement.
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影响因子：
6
作者：
Baicy, Kate;London, Edythe D.
通讯作者：
London, Edythe D.
影响因子：
4.2
作者：
Charntikov, Sergios;Pittenger, Steven T.;Pendyala, Gurudutt
通讯作者：
Pendyala, Gurudutt
影响因子：
6
作者：
Carter, BL;Tiffany, ST
通讯作者：
Tiffany, ST
影响因子：
3.4
作者：
COMER, SD;LAC, ST;CARROLL, ME
通讯作者：
CARROLL, ME
DOI：
10.1523/jneurosci.0005-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bossert JM;Stern AL;Theberge FR;Marchant NJ;Wang HL;Morales M;Shaham Y
通讯作者：
Shaham Y