Master Regulators in Plant Glucose Signaling Networks.
Master Regulators in Plant Glucose Signaling Networks.
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DOI：
10.1007/s12374-014-0902-7
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发表时间：
2014-04
影响因子：
2.9
通讯作者：
Sheen, Jen
中科院分区：
文献类型：
--
作者：
Sheen, Jen
光合作用植物的日常生活围绕着糖的生产、运输、储存和利用，复杂的糖代谢和信号网络整合了内部调节和环境信号来调控和维持植物的生长和生存。虽然从胚胎发育到衰老，各种糖信号都是关键的调节信号，但葡萄糖是最古老和最保守的调节信号，它控制着基因和蛋白质的表达，细胞周期的进展，中央和次生代谢，以及生长和发育程序。葡萄糖信号通过两种主要机制被感知和传递：通过葡萄糖传感器的直接感知和通过各种能量和代谢物传感器的间接感知。本文综述了拟南芥中三种葡萄糖调节主调控子、己酮酸酶1(HXK1)葡萄糖感受器、被葡萄糖失活的能量感受器KIN10/KIN11和葡萄糖激活靶标雷帕霉素(TOR)的比较和功能分析。这些调节子在进化上是保守的，但在植物和动物中进化出了普遍和独特的调节线路和功能。它们与多个伙伴形成蛋白质复合体，作为调节器或效应器，在不同的亚细胞场所和器官中发挥不同的功能，在植物葡萄糖信号网络中发挥着从细胞信号和代谢到发育的综合和互补作用。
The daily life of photosynthetic plants revolves around sugar production, transport, storage and utilization, and the complex sugar metabolic and signaling networks integrate internal regulators and environmental cues to govern and sustain plant growth and survival. Although diverse sugar signals have emerged as pivotal regulators from embryogenesis to senescence, glucose is the most ancient and conserved regulatory signal that controls gene and protein expression, cell-cycle progression, central and secondary metabolism, as well as growth and developmental programs. Glucose signals are perceived and transduced by two principal mechanisms: direct sensing through glucose sensors and indirect sensing via a variety of energy and metabolite sensors. This review focuses on the comparative and functional analyses of three glucose-modulated master regulators in Arabidopsis thaliana, the hexokinase1 (HXK1) glucose sensor, the energy sensor kinases KIN10/KIN11 inactivated by glucose, and the glucose-activated target of rapamycin (TOR) kinase. These regulators are evolutionarily conserved, but have evolved universal and unique regulatory wiring and functions in plants and animals. They form protein complexes with multiple partners as regulators or effectors to serve distinct functions in different subcellular locales and organs, and play integrative and complementary roles from cellular signaling and metabolism to development in the plant glucose signaling networks.
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影响因子：
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作者：
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