Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
Fgf9 from dermal γδ T cells induces hair follicle neogenesis after wounding.
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作者：
了解毛囊再生的分子机制为开发脱发和其他皮肤疾病的治疗方法提供了新的机会。在这里，我们发现成纤维细胞生长因子9（Fgf9），最初由γδ T细胞分泌，调节成年小鼠皮肤受伤后的毛囊再生。减少Fgf9表达会降低这种创伤诱导的毛发新生（WIHN）。相反，Fgf9的过表达导致新生毛囊数量增加2至3倍。我们发现，来自γδ T细胞的Fgf9触发伤口成纤维细胞中的Wnt表达和随后的Wnt活化。通过独特的反馈机制，活化的成纤维细胞然后表达Fgf9，从而在皮肤再生的关键阶段放大整个伤口真皮的Wnt活性。值得注意的是，人类缺乏强大的常驻真皮γδ T细胞群体，这可能解释了他们在受伤后无法再生毛发的原因。这些发现强调了免疫系统和组织再生之间的重要关系。Fgf9在毛囊再生中的重要性表明它可以用于人类的治疗。
Understanding molecular mechanisms for regeneration of hair follicles provides new opportunities for developing treatments for hair loss and other skin disorders. Here we show that fibroblast growth factor 9 (Fgf9), initially secreted by γδ T cells, modulates hair follicle regeneration after wounding the skin of adult mice. Reducing Fgf9 expression decreases this wound-induced hair neogenesis (WIHN). Conversely, overexpression of Fgf9 results in a two- to threefold increase in the number of neogenic hair follicles. We found that Fgf9 from γδ T cells triggers Wnt expression and subsequent Wnt activation in wound fibroblasts. Through a unique feedback mechanism, activated fibroblasts then express Fgf9, thus amplifying Wnt activity throughout the wound dermis during a crucial phase of skin regeneration. Notably, humans lack a robust population of resident dermal γδ T cells, potentially explaining their inability to regenerate hair after wounding. These findings highlight the essential relationship between the immune system and tissue regeneration. The importance of Fgf9 in hair follicle regeneration suggests that it could be used therapeutically in humans.
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影响因子：
4.4
作者：
Andrew, EM;Newton, DJ;Carding, SR
通讯作者：
Carding, SR
影响因子：
5.3
作者：
Lustig, B;Jerchow, B;Behrens, J
通讯作者：
Behrens, J
影响因子：
11.2
作者：
Hendrix, ND;Wu, R;Cho, KR
通讯作者：
Cho, KR
影响因子：
15.3
作者：
FOSTER, CA;YOKOZEKI, H;STINGL, G
通讯作者：
STINGL, G
DOI：
10.1084/jem.20101824
发表时间：
2011-03-14
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Sumaria N;Roediger B;Ng LG;Qin J;Pinto R;Cavanagh LL;Shklovskaya E;Fazekas de St Groth B;Triccas JA;Weninger W
通讯作者：
Weninger W