Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells.
Cutaneous immunosurveillance by self-renewing dermal gammadelta T cells.
复制标题
DOI：
10.1084/jem.20101824
复制
发表时间：
2011-03-14
期刊：
影响因子：
--
通讯作者：
Weninger W
中科院分区：
文献类型：
--
作者：
Sumaria N;Roediger B;Ng LG;Qin J;Pinto R;Cavanagh LL;Shklovskaya E;Fazekas de St Groth B;Triccas JA;Weninger W
真皮含有不同于表皮γδ T细胞的新型γδT细胞群，其响应于分枝杆菌感染而产生IL-17。小鼠表皮中存在γδ T细胞受体（TCR）表达细胞，称为树突状表皮T细胞（DETC），这一点已得到充分证实。由于其严格的表皮定位，DETC可能主要响应于上皮应激，例如感染或转化细胞的存在，而它们可能不直接参与真皮免疫应答。在这项研究中，我们描述了一个突出的居民真皮γδ T细胞，这不同于在TCR的使用，表型和迁移行为的DETC人口。真皮γδ T细胞具有放射抗性，原位循环，并且其发育和存活部分依赖于白细胞介素（IL）-7，而不是IL-15。在分枝杆菌感染期间，真皮γδ T细胞是产生IL-17的主要真皮细胞。真皮γδ T细胞的缺乏与免疫显性结核分枝杆菌表位特异性的CD 4 + T细胞在皮肤引流淋巴结中的扩增减少相关。CD 4 + T细胞扩增减少与中性粒细胞向皮肤募集减少和BCG向引流淋巴结穿梭减少有关。因此，真皮γδ T细胞是居民皮肤免疫监视程序的重要组成部分。我们的数据证明了皮肤不同微区室中T细胞的功能特化。
The dermis contains a novel population of γδT cells that are distinct from epidermal γδT cells and produce IL-17 in response to mycobacterial infection. The presence of γδ T cell receptor (TCR)–expressing cells in the epidermis of mice, termed dendritic epidermal T cells (DETCs), is well established. Because of their strict epidermal localization, it is likely that DETCs primarily respond to epithelial stress, such as infections or the presence of transformed cells, whereas they may not participate directly in dermal immune responses. In this study, we describe a prominent population of resident dermal γδ T cells, which differ from DETCs in TCR usage, phenotype, and migratory behavior. Dermal γδ T cells are radioresistant, cycle in situ, and are partially depend on interleukin (IL)-7, but not IL-15, for their development and survival. During mycobacterial infection, dermal γδ T cells are the predominant dermal cells that produce IL-17. Absence of dermal γδ T cells is associated with decreased expansion in skin draining lymph nodes of CD4+ T cells specific for an immunodominant Mycobacterium tuberculosis epitope. Decreased CD4+ T cell expansion is related to a reduction in neutrophil recruitment to the skin and decreased BCG shuttling to draining lymph nodes. Thus, dermal γδ T cells are an important part of the resident cutaneous immunosurveillance program. Our data demonstrate functional specialization of T cells in distinct microcompartments of the skin.
登录
查看更多内容
DOI：
10.1073/pnas.86.11.4185
发表时间：
1989-06-01
影响因子：
11.1
作者：
HAVRAN, WL;GRELL, S;ALLISON, JP
通讯作者：
ALLISON, JP
影响因子：
64.8
作者：
HEILIG, JS;TONEGAWA, S
通讯作者：
TONEGAWA, S
影响因子：
4.4
作者：
Chinnery, Holly R.;Ruitenberg, Marc J.;McMenamin, Paul G.
通讯作者：
McMenamin, Paul G.
影响因子：
15.3
作者：
FOSTER, CA;YOKOZEKI, H;STINGL, G
通讯作者：
STINGL, G
影响因子：
30.5
作者：
Bromley, SK;Thomas, SY;Luster, AD
通讯作者：
Luster, AD