Cellular and molecular changes in orthodontic tooth movement.
Cellular and molecular changes in orthodontic tooth movement.
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DOI：
10.1100/2011/761768
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发表时间：
2011
影响因子：
--
通讯作者：
Zainal Ariffin Z
中科院分区：
文献类型：
--
作者：
Zainal Ariffin SH;Yamamoto Z;Zainol Abidin IZ;Megat Abdul Wahab R;Zainal Ariffin Z
正畸治疗引起的牙齿移动会引起牙周组织和牙槽骨的连续反应，导致牙组织和周围结构释放大量物质。为了更好地了解正畸治疗中涉及的生物过程、改善治疗并减少不良副作用，其中几种物质已被提议作为生物标志物。潜在的生物标记物可以从不同的组织样本中收集，适当的采样对于准确反映生物过程非常重要。本文涵盖了正畸牙齿移动过程中涉及的组织变化，例如压缩区（涉及成骨细胞）、张力区（涉及破骨细胞）、牙根和牙髓组织。此外，还解释了正畸治疗过程中干细胞的参与及其向成骨细胞和破骨细胞的发育。还提出了代表特定现象（即骨重塑（形成和吸收）、炎症和牙根吸收）期间这些生物变化的几种可能的生物标志物。这些生物标志物的知识可用于加速正畸治疗。
Tooth movement induced by orthodontic treatment can cause sequential reactions involving the periodontal tissue and alveolar bone, resulting in the release of numerous substances from the dental tissues and surrounding structures. To better understand the biological processes involved in orthodontic treatment, improve treatment, and reduce adverse side effects, several of these substances have been proposed as biomarkers. Potential biological markers can be collected from different tissue samples, and suitable sampling is important to accurately reflect biological processes. This paper covers the tissue changes that are involved during orthodontic tooth movement such as at compression region (involving osteoblasts), tension region (involving osteoclasts), dental root, and pulp tissues. Besides, the involvement of stem cells and their development towards osteoblasts and osteoclasts during orthodontic treatment have also been explained. Several possible biomarkers representing these biological changes during specific phenomenon, that is, bone remodelling (formation and resorption), inflammation, and root resorption have also been proposed. The knowledge of these biomarkers could be used in accelerating orthodontic treatment.
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