Compulsive Addiction-like Aggressive Behavior in Mice.
Compulsive Addiction-like Aggressive Behavior in Mice.
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DOI：
10.1016/j.biopsych.2017.03.004
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发表时间：
2017-08-15
影响因子：
10.6
通讯作者：
Shaham Y
中科院分区：
文献类型：
--
作者：
Golden SA;Heins C;Venniro M;Caprioli D;Zhang M;Epstein DH;Shaham Y
有些人有很高的动机去寻求攻击性的遭遇，在那些因这种行为而被监禁的人中，累犯率很高。这些观察结果反映了药物成瘾的两个核心特征：尽管有不良后果，但仍有很高的动机去寻找成瘾物质，以及高复发率。在这里，我们使用已建立的啮齿动物药物成瘾模型，以确定他们是否会敏感的“成瘾样”的CD-1小鼠的攻击功能。在Exp.如图1-2所示，我们训练较老的CD-1小鼠来挤压以获得攻击较年轻的C57 BL 6/J小鼠的机会。然后，我们测试了他们在强迫禁欲或惩罚诱导的攻击自我管理抑制后的攻击复发。在Exp. 3、我们训练了一个大的CD-1小鼠队列，并测试了它们基于选择的攻击寻求自愿抑制、攻击寻求复发、渐进比率反应和惩罚诱导的攻击自我抑制。然后，我们使用聚类分析来确定强迫性“成瘾样”攻击行为的个体差异模式。在Exp. 1-2，我们观察到强烈的动机，以获得操作性自我管理的机会，攻击，和复发的脆弱性，在禁欲。在Exp. 3、攻击相关指标的聚类分析确定了一个“成瘾”小鼠子集（约19%），其表现出强烈的操作性强化攻击行为，选择替代攻击者的可能性降低，复发脆弱性和渐进比率反应增强，以及对惩罚诱导的攻击行为抑制的恢复力。利用建立的药物成瘾模型程序，我们发现CD-1小鼠的一个亚群表现出“成瘾样”攻击行为，表明病理性攻击的进化起源。
Some people are highly motivated to seek aggressive encounters, and among those who have been incarcerated for such behavior, recidivism rates are high. These observations echo two core features of drug addiction: high motivation to seek addictive substances, despite adverse consequences, and high relapse rates. Here we used established rodent models of drug addiction to determine whether they would be sensitive to “addiction-like” features of aggression in CD-1 mice. In Exp. 1–2, we trained older CD-1 mice to lever-press for opportunities to attack younger C57BL6/J mice. We then tested them for relapse to aggression seeking after forced abstinence or punishment-induced suppression of aggression self-administration. In Exp. 3, we trained a large cohort of CD-1 mice, and tested them for choice-based voluntary suppression of aggression seeking, relapse to aggression seeking, progressive ratio responding, and punishment-induced suppression of aggression self-administration. We then used cluster analysis to identify patterns of individual differences in compulsive “addiction-like” aggressive behavior. In Exp. 1–2, we observed strong motivation to acquire operant self-administration of opportunities to aggress, and relapse vulnerability during abstinence. In Exp. 3, cluster analysis of the aggression-related measures identified a subset of “addicted” mice (~19%) that exhibited intense operant-reinforced attack behavior, decreased likelihood to select an alternative reinforcer over aggression, heightened relapse vulnerability and progressive ratio responding, and resilience to punishment-induced suppression of aggressive behavior. Using procedures established to model drug addiction, we showed that a subpopulation of CD-1 mice demonstrate “addiction-like” aggressive behavior, suggesting an evolutionary origin for pathological aggression.
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影响因子：
10.6
作者：
Caprioli D;Venniro M;Zeric T;Li X;Adhikary S;Madangopal R;Marchant NJ;Lucantonio F;Schoenbaum G;Bossert JM;Shaham Y
通讯作者：
Shaham Y
影响因子：
2.3
作者：
Anthony, James C.;Warner, Lynn A.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
成年雄性有性经历的 CD-1 小鼠对攻击经历的持续条件性位置偏好。
DOI：
10.1111/gbb.12310
发表时间：
2017-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Golden SA;Aleyasin H;Heins R;Flanigan M;Heshmati M;Takahashi A;Russo SJ;Shaham Y
通讯作者：
Shaham Y
影响因子：
64.8
作者：
Golden SA;Heshmati M;Flanigan M;Christoffel DJ;Guise K;Pfau ML;Aleyasin H;Menard C;Zhang H;Hodes GE;Bregman D;Khibnik L;Tai J;Rebusi N;Krawitz B;Chaudhury D;Walsh JJ;Han MH;Shapiro ML;Russo SJ
通讯作者：
Russo SJ
影响因子：
25
作者：
Falkner AL;Grosenick L;Davidson TJ;Deisseroth K;Lin D
通讯作者：
Lin D