Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.

Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.
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高分辨率fMRI的时间依赖性空间特异性:对介质神经血管耦合的见解。

DOI:
10.1098/rstb.2019.0623
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发表时间:
2021-01-04
期刊:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子:
--
通讯作者:
Kim SG
Kim SG
中科院分区:
其他
文献类型:
--
作者:
Fukuda M;Poplawsky AJ;Kim SG

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高分辨率功能磁共振成像(fMRI)正变得越来越受欢迎,因为超高磁场的可用性越来越高,能够提高灵敏度和空间分辨率。然而,对于基于血流动力学的技术,如功能磁共振成像(fMRI),提高空间分辨率是否能准确检测到神经元活动的真实位置,还存在争议。我们利用基于血红蛋白的光学成像和不同的功能磁共振成像对比(如血氧水平依赖、脑血流量和脑血容量),在动物的功能柱和层中解决了这个问题。在这篇综述中,我们主要从我们自己的研究中描述了这些fMRI信号对神经元活动部位的空间特异性的经验证据,并讨论了中尺度神经血管耦合的见解。这篇文章是主题“非侵入性功能性神经成像与潜在神经元活动之间的关键关系”的一部分。
High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly popular because of the growing availability of ultra-high magnetic fields which are capable of improving sensitivity and spatial resolution. However, it is debatable whether increased spatial resolutions for haemodynamic-based techniques, like fMRI, can accurately detect the true location of neuronal activity. We have addressed this issue in functional columns and layers of animals with haemoglobin-based optical imaging and different fMRI contrasts, such as blood oxygenation level-dependent, cerebral blood flow and cerebral blood volume fMRI. In this review, we describe empirical evidence primarily from our own studies on how well these fMRI signals are spatially specific to the neuronally active site and discuss insights into neurovascular coupling at the mesoscale. This article is part of the theme issue ‘Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity’.
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