Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.
Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling.
复制标题
高分辨率fMRI的时间依赖性空间特异性:对介质神经血管耦合的见解。
DOI:
10.1098/rstb.2019.0623
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发表时间:
2021-01-04
期刊:
影响因子:
--
通讯作者:
Kim SG
中科院分区:
文献类型:
--
作者:
Fukuda M;Poplawsky AJ;Kim SG
High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly popular because of the growing availability of ultra-high magnetic fields which are capable of improving sensitivity and spatial resolution. However, it is debatable whether increased spatial resolutions for haemodynamic-based techniques, like fMRI, can accurately detect the true location of neuronal activity. We have addressed this issue in functional columns and layers of animals with haemoglobin-based optical imaging and different fMRI contrasts, such as blood oxygenation level-dependent, cerebral blood flow and cerebral blood volume fMRI. In this review, we describe empirical evidence primarily from our own studies on how well these fMRI signals are spatially specific to the neuronally active site and discuss insights into neurovascular coupling at the mesoscale. This article is part of the theme issue ‘Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity’.
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