The role of oral microbiome in periodontitis under diabetes mellitus.
The role of oral microbiome in periodontitis under diabetes mellitus.
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DOI：
10.1080/20002297.2022.2078031
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发表时间：
2022
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
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牙周炎是人类最常见的炎症性疾病之一，其特征是支持牙齿的组织遭到破坏，最终导致牙齿脱落。糖尿病(DM)是一组以胰岛素分泌缺陷和/或胰岛素抵抗引起的慢性高血糖为特征的代谢性疾病。许多研究已经为糖尿病和牙周炎之间的相互关系提供了证据，牙周炎被认为是糖尿病的第六大常见并发症。然而，其机制尚不完全清楚。DM通过高血糖和炎症途径对牙周炎的影响已被很好地描述，但根据先前的研究，DM对口腔微生物区系的影响仍然存在争议。最近利用下一代测序技术进行的研究表明，DM可以改变口腔微生物组的生物多样性和组成，尤其是龈下微生物组。这可能是糖尿病风险或加重牙周炎的另一种机制。因此，了解口腔微生物群在糖尿病患者牙周炎中的作用以及糖尿病时口腔微生物群移位的机制，对于制定治疗糖尿病牙周炎或预防糖尿病患者牙周炎的具体治疗方案具有重要意义。本文综述了口腔微生物群在牙周健康(共生)和疾病(生物失调)中的作用，重点介绍了糖尿病下口腔微生物的变化，并总结了这些变化的机制。
Periodontitis is among most common human inflammatory diseases and characterized by destruction of tooth-supporting tissues that will eventually lead to tooth loss. Diabetes mellitus (DM) is a group of metabolic disorders characterized by chronic hyperglycemia which results from defects in insulin secretion and/or insulin resistance. Numerous studies have provided evidence for the inter-relationship between DM and periodontitis that has been considered as the sixth most frequent complication of DM. However, the mechanisms are not fully understood yet. The impact of DM on periodontitis through hyperglycemia and inflammatory pathways is well described, but the effects of DM on oral microbiota remain controversial according to previous studies. Recent studies using next-generation sequencing technology indicate that DM can alter the biodiversity and composition of oral microbiome especially subgingival microbiome. This may be another mechanism by which DM risks or aggravates periodontitis. Thus, to understand the role of oral microbiome in periodontitis of diabetics and the mechanism of shifts of oral microbiome under DM would be valuable for making specific therapeutic regimens for treating periodontitis patients with DM or preventing diabetic patients from periodontitis. This article reviews the role of oral microbiome in periodontal health (symbiosis) and disease (dysbiosis), highlights the oral microbial shifts under DM and summarizes the mechanism of the shifts.
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影响因子：
11
作者：
Duran-Pinedo, Ana E.;Chen, Tsute;Frias-Lopez, Jorge
通讯作者：
Frias-Lopez, Jorge
综合宏基因组数据分析表明，口腔微生物群多样性的丧失与牙周炎有关
影响因子：
4.4
作者：
Ai D;Huang R;Wen J;Li C;Zhu J;Xia LC
通讯作者：
Xia LC
影响因子：
5.8
作者：
Bastos, Alliny S.;Graves, Dana T.;Orrico, Silvana R. P.
通讯作者：
Orrico, Silvana R. P.
影响因子：
5.1
作者：
Cho, N. H.;Shaw, J. E.;Malanda, B.
通讯作者：
Malanda, B.
DOI：
10.1038/ismej.2010.30
发表时间：
2010-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
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