Genome-wide identification and analysis of expression profiles of maize mitogen-activated protein kinase kinase kinase.
Genome-wide identification and analysis of expression profiles of maize mitogen-activated protein kinase kinase kinase.
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玉米丝裂原激活蛋白激酶的全基因组鉴定和表达谱分析
DOI：
10.1371/journal.pone.0057714
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Kong X;Lv W;Zhang D;Jiang S;Zhang S;Li D
丝裂原活化蛋白激酶（MAPK）级联是动物、酵母和植物中高度保守的信号转导模型。植物MAPK级联与发育和胁迫反应有关。虽然MAPKKK已经在包括拟南芥和水稻在内的几种植物物种中进行了研究，但尚未在玉米中进行系统的分析。在这项研究中，我们对整个玉米基因组进行了生物信息学分析，并确定了74个MAPKKK基因。系统发育分析表明，玉米、水稻和拟南芥中的MAPKKKs可分为Raf、ZIK和MEKK三个亚类。亚家族内的进化关系也得到了外显子-内含子组织和保守蛋白基序的支持。对MAPKKKs基因表达谱的进一步分析表明，MAPKKKs基因在玉米不同器官和发育阶段参与了重要的信号传导途径。我们对玉米MAPKKK基因的基因组学分析为该家族在玉米中的进化和功能研究提供了重要信息。
Mitogen-activated protein kinase (MAPK) cascades are highly conserved signal transduction model in animals, yeast and plants. Plant MAPK cascades have been implicated in development and stress responses. Although MAPKKKs have been investigated in several plant species including Arabidopsis and rice, no systematic analysis has been conducted in maize. In this study, we performed a bioinformatics analysis of the entire maize genome and identified 74 MAPKKK genes. Phylogenetic analyses of MAPKKKs from maize, rice and Arabidopsis have classified them into three subgroups, which included Raf, ZIK and MEKK. Evolutionary relationships within subfamilies were also supported by exon-intron organizations and the conserved protein motifs. Further expression analysis of the MAPKKKs in microarray databases revealed that MAPKKKs were involved in important signaling pathways in maize different organs and developmental stages. Our genomics analysis of maize MAPKKK genes provides important information for evolutionary and functional characterization of this family in maize.
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影响因子：
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DOI：
10.1073/pnas.0907205106
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