A porcine model of full-thickness burn, excision and skin autografting.
A porcine model of full-thickness burn, excision and skin autografting.
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DOI：
10.1016/j.burns.2008.03.013
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Jeschke MG
中科院分区：
文献类型：
--
作者：
Branski LK;Mittermayr R;Herndon DN;Norbury WB;Masters OE;Hofmann M;Traber DL;Redl H;Jeschke MG
急性烧伤创面通常需要早期切除并进行适当的覆盖，以防止进一步的体温过低、蛋白质和液体流失以及感染风险。网状自体皮肤移植通常被认为是大面积全层烧伤的标准治疗方法。然而，移植物的吸收和伤口愈合的速度取决于几个内源性因素。本文描述了一种标准化的可重复的猪烧伤和皮肤移植模型，该模型可用于研究局部治疗对移植和再上皮化的影响。程序为成功的猪烧伤实验提供了一个方案，特别关注术前护理，麻醉，烧伤分配，切除和移植，术后治疗，敷料应用和标本采集。选择的结果测量包括通过平面测量的伤口愈合面积百分比，使用临床评估量表的伤口评估和组织学评分。这种标准化模型的使用为烧伤研究人员提供了一种有价值的工具，可以在模拟临床现实的环境中比较不同的局部药物治疗和敷料。
Acute burn wounds often require early excision and adequate coverage to prevent further hypothermia, protein and fluid losses, and the risk of infection. Meshed autologous skin grafts are generally regarded as the standard treatment for extensive full-thickness burns. Graft take and rate of wound healing, however, depend on several endogenous factors. This paper describes a standardized reproducible porcine model of burn and skin grafting which can be used to study the effects of topical treatments on graft take and re-epithelialization. Procedures provide a protocol for successful porcine burn wound experiments with special focus on pre-operative care, anesthesia, burn allocation, excision and grafting, postoperative treatment, dressing application, and specimen collection. Selected outcome measurements include percent area of wound closure by planimetry, wound assessment using a clinical assessment scale, and histological scoring. The use of this standardized model provides burn researchers with a valuable tool for the comparison of different topical drug treatments and dressing materials in a setting that closely mimics clinical reality.
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