Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine.
Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine.
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DOI：
10.1039/d0cs00908c
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发表时间：
2021-04-07
影响因子：
46.2
通讯作者：
Jokerst JV
中科院分区：
文献类型：
--
作者：
Wu D ;Zhou J ;Creyer MN ;Yim W ;Chen Z ;Messersmith PB ;Jokerst JV
酚类化合物在自然界中普遍存在，由于其独特的理化性质和广泛的工业用途而获得了极大的研究关注。近几十年来，它们的可及性、多功能反应性和相对的生物相容性催化了酚醛启用纳米技术（PEN）的研究，特别是生物医学应用，这是这种出现的主要受益者，聚多巴胺和多酚在很大程度上证明了这一点。因此，有必要对PEN的基本作用机制和合成策略进行综述，并提供一个及时和全面的总结。在这篇综述中，我们将重点介绍PEN的原理和策略，并总结PEN合成工具包在粒子工程和自底向上合成纳米杂化材料中的应用。具体来说，我们将讨论限制颗粒系统中酚类化合物和互补结构基序之间的吸引力，以合成具有可控尺寸，形状，组成以及表面化学和功能的高质量产品。此外，酚类化合物在生物传感、生物成像和疾病治疗方面的众多应用也将得到强调。这篇综述旨在为该领域的新科学家提供指导方针，并作为这一领域所取得成就的最新汇编，同时提供有关PEN在翻译研究中的使用的专家观点。
Phenolics are ubiquitous in nature and have gained immense research attention because of their unique physiochemical properties and widespread industrial use. In recent decades, their accessibility, versatile reactivity, and relative biocompatibility have catalysed research in phenolic-enabled nanotechnology (PEN) particularly for biomedical applications which have been a major benefactor of this emergence, as largely demonstrated by polydopamine and polyphenols. Therefore, it is imperative to overveiw the fundamental mechanisms and synthetic strategies of PEN for state-of-the-art biomedical applications and provide a timely and comprehensive summary. In this review, we will focus on the principles and strategies involved in PEN and summarize the use of the PEN synthetic toolkit for particle engineering and the bottom-up synthesis of nanohybrid materials. Specifically, we will discuss the attractive forces between phenolics and complementary structural motifs in confined particle systems to synthesize high-quality products with controllable size, shape, composition, as well as surface chemistry and function. Additionally, phenolic’s numerous applications in biosensing, bioimaging, and disease treatment will be highlighted. This review aims to provide guidelines for new scientists in the field and serve as an up-to-date compilation of what has been achieved in this area, while offering expert perspectives on PEN’s use in translational research.
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