Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes.
Three-dimensional high-resolution imaging of gold nanorods uptake in sentinel lymph nodes.
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前哨淋巴结中金纳米棒摄取的三维高分辨率成像。
DOI:
10.1021/nl2014394
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发表时间:
2011-07-13
期刊:
影响因子:
10.8
通讯作者:
Wang RK
中科院分区:
文献类型:
--
作者:
Jung Y;Reif R;Zeng Y;Wang RK
In this paper, we demonstrate an application of a non-invasive imaging modality, photothermal optical coherence tomography (PT-OCT), for imaging gold nanorods (GNRs) uptake in sentinel lymph node (SLN) of mice in situ. This application enables us to obtain higher quality images of SLN structures due to the photothermal contrast properties of the GNRs. It is also demonstrated that GNRs accumulate differently within several SLN structures, and this uptake is time dependent. Finally, we determine the average concentration of GNRs within the whole SLN which is used to demonstrate uptake kinetics of the nanoparticles.
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