Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.
Signaling integration in the rugae growth zone directs sequential SHH signaling center formation during the rostral outgrowth of the palate.
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DOI：
10.1016/j.ydbio.2009.09.028
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发表时间：
2009-12-01
影响因子：
2.7
通讯作者：
O'Brien, Timothy P.
中科院分区：
文献类型：
--
作者：
Welsh, Ian C.;O'Brien, Timothy P.
关键词：
面部形态的演变源于发育调节网络活动的变化，这些网络指导特定颅面元素的形成。重要的是，新形态的获得必须与遗传学遗传的发育程序相结合。我们已经确定了一个独特的区域的第二腭与周期性形成的皱纹在嘴的生长的脸。皱褶作为SHH信号中心，对腭架的延伸起着决定性的作用。我们已经发现，一个网络的信号基因和转录因子的空间组织相对于腭皱。此外，第一个形成的皱褶战略性地定位在未来硬腭和软腭的假定交界处，该交界处定义了区域生长、间充质基因表达和细胞命运的前后差异。我们提出了一个分子电路整合成纤维细胞生长因子和骨形态发生蛋白信号，以控制增殖和分化过程中的皱褶和皱褶间域在腭上皮的顺序形成。p63和Sostdc1表达的丧失和皱褶分化的失败突出了协调的上皮间充质信号传导在Fgf10突变体腭中的丧失。我们的研究结果建立了一个遗传程序，粘附组织信号结构域，以协调增长的第二腭与延长面中部复合体。
Evolution of facial morphology arises from variation in the activity of developmental regulatory networks that guide the formation of specific craniofacial elements. Importantly, the acquisition of novel morphology must be integrated with a phylogenetically inherited developmental program. We have identified a unique region of the secondary palate associated with the periodic formation of rugae during the rostral outgrowth of the face. Rugae function as SHH signaling centers to pattern the elongating palatal shelves. We have found that a network of signaling genes and transcription factors is spatially organized relative to palatal rugae. Additionally, the first formed ruga is strategically positioned at the presumptive junction of the future hard and soft palate that defines anterior-posterior differences in regional growth, mesenchymal gene expression and cell fate. We propose a molecular circuit integrating FGF and BMP signaling to control proliferation and differentiation during the sequential formation of rugae and inter-rugae domains in the palatal epithelium. The loss of p63 and Sostdc1 expression and failed rugae differentiation highlight that coordinated epithelial mesenchymal signaling is lost in the Fgf10 mutant palate. Our results establish a genetic program that reiteratively organizes signaling domains to coordinate the growth of the secondary palate with the elongating midfacial complex.
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DOI：
10.1002/jez.b.21205
发表时间：
2008-06-15
影响因子：
2.2
作者：
Depew, Michael J.;Compagnucci, Claudia
通讯作者：
Compagnucci, Claudia
影响因子：
4.6
作者：
Hu, D;Marcucio, RS;Helms, JA
通讯作者：
Helms, JA
影响因子：
2.5
作者：
Casey, Liam M.;Lan, Yu;Jiang, Rulang
通讯作者：
Jiang, Rulang
影响因子：
4.6
作者：
Haworth, KE;Healy, C;Sharpe, PT
通讯作者：
Sharpe, PT
影响因子：
2.7
作者：
Firnberg, N;Neubüser, A
通讯作者：
Neubüser, A