Sexual orientation modulates endocrine stress reactivity.
Sexual orientation modulates endocrine stress reactivity.
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DOI：
10.1016/j.biopsych.2014.08.013
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发表时间：
2015-04-01
影响因子：
10.6
通讯作者：
Pruessner JC
中科院分区：
文献类型：
--
作者：
Juster RP;Hatzenbuehler ML;Mendrek A;Pfaus JG;Smith NG;Johnson PJ;Lefebvre-Louis JP;Raymond C;Marin MF;Sindi S;Lupien SJ;Pruessner JC
生物性别差异和社会文化性别多样性影响内分泌应激反应。尽管许多研究表明，当暴露于基于实验室的心理社会压力源时，男性通常会比女性激活更强的压力反应，但尚不清楚性取向是否会进一步调节压力反应。鉴于女同性恋，男同性恋和双性恋（LGB）的个人经常报告加剧的痛苦继发于污名相关的压力，我们调查皮质醇压力反应是否LGB个人和异性恋个体之间的差异，以响应一个良好的验证心理社会压力。研究人群包括87名健康成年人（平均年龄25岁），根据他们的生物学性别和性别性取向分组：女同性恋/双性恋女性（n = 20），异性恋女性（n = 21），男同性恋/双性恋男性（n = 26）和异性恋男性（n = 20）。研究人员在下午2小时的访问中收集了10份唾液皮质醇样本，其中包括经过修改的特里尔社会压力测试，以最大限度地提高性别差异。相对于异性恋女性，女同性恋/双性恋女性暴露于应激源后40分钟表现出更高的皮质醇应激反应。相比之下，同性恋/双性恋男性在整个测试过程中显示出较低的整体皮质醇浓度与异性恋男性相比。在调整性激素（女性雌二醇与孕酮的比例和男性睾酮），年龄，自尊和披露状态（LGB参与者是否完成了他们的“出柜”）时，主要发现是显着的。我们的研究结果提供了新的证据，基于性别的皮质醇应激反应的调制性取向的基础上，超越了既定的性别之间的差异。这项研究提出了几个重要的途径，为未来的研究有关的生理功能的LGB人口和性别多样性更广泛。
Biological sex differences and sociocultural gender diversity influence endocrine stress reactivity. Although numerous studies have shown that men typically activate stronger stress responses than women when exposed to laboratory-based psychosocial stressors, it is unclear whether sexual orientation further modulates stress reactivity. Given that lesbian, gay, and bisexual (LGB) individuals frequently report heightened distress secondary to stigma-related stressors, we investigated whether cortisol stress reactivity differs between LGB individuals and heterosexual individuals in response to a well-validated psychosocial stressor. The study population comprised 87 healthy adults (mean age, 25 years) who were grouped according to their biological sex and their gendered sexual orientation: lesbian/bisexual women (n = 20), heterosexual women (n = 21), gay/bisexual men (n = 26), and heterosexual men (n = 20). Investigators collected 10 salivary cortisol samples throughout a 2-hour afternoon visit involving exposure to the Trier Social Stress Test modified to maximize between-sex differences. Relative to heterosexual women, lesbian/bisexual women showed higher cortisol stress reactivity 40 min after exposure to the stressor. In contrast, gay/bisexual men displayed lower overall cortisol concentrations throughout testing compared with heterosexual men. Main findings were significant while adjusting for sex hormones (estradiol-to-progesterone ratio in women and testosterone in men), age, self-esteem, and disclosure status (whether LGB participants had completed their “coming out”). Our results provide novel evidence for gender-based modulation of cortisol stress reactivity based on sexual orientation that goes beyond well-established between-sex differences. This study raises several important avenues for future research related to the physiologic functioning of LGB populations and gender diversity more broadly.
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影响因子：
3.7
作者：
Granger, DA;Shirtcliff, EA;Schwartz, EB
通讯作者：
Schwartz, EB
影响因子：
3.2
作者：
KIRSCHBAUM, C;PIRKE, KM;HELLHAMMER, DH
通讯作者：
HELLHAMMER, DH
影响因子：
3.3
作者：
KIRSCHBAUM, C;WUST, S;HELLHAMMER, D
通讯作者：
HELLHAMMER, D
影响因子：
2.6
作者：
BANKS, A;GARTRELL, NK
通讯作者：
GARTRELL, NK
影响因子：
1.9
作者：
Andrews, Julie;Wadiwalla, Mehereen;Pruessner, Jens C.
通讯作者：
Pruessner, Jens C.