Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers.
Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers.
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NK 细胞上程序性细胞死亡蛋白 1 的表达增加会抑制 NK 细胞介导的抗肿瘤功能，并表明消化道癌症的预后不良
作者：
Liu Y;Cheng Y;Xu Y;Wang Z;Du X;Li C;Peng J;Gao L;Liang X;Ma C
Abnormal expression of activating/inhibitory receptors leads to natural killer (NK) cells dysfunction in tumor. Here we show that programmed cell death protein 1 (PD-1), a well-known immune checkpoint of T cells, is highly expressed on peripheral and tumor-infiltrating NK cells from patients with digestive cancers including esophageal, liver, colorectal, gastric and biliary cancer. The increased PD-1 expression on NK cells indicates poorer survival in esophageal and liver cancers. Blocking PD-1/PD-L1 signaling markedly enhances cytokines production and degranulation and suppresses apoptosis of NK cells in vitro. PD-1/PD-L1 exerts inhibitory effect through repressing the activation of PI3K/AKT signaling in NK cells. More importantly, a PD-1 blocking antibody was found to significantly suppress the growth of xenografts in nude mice, and this inhibition of tumor growth was completely abrogated by NK depletion. These findings strongly suggested that PD-1 is an inhibitory regulator of NK cells in digestive cancers. PD-1 blockade might be an efficient strategy in NK cell-based tumor immunotherapy.
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影响因子：
8
作者：
通讯作者：
--
DOI：
10.1038/nrc3239
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Pardoll DM
通讯作者：
Pardoll DM
影响因子：
7.3
作者：
Ali AK;Nandagopal N;Lee SH
通讯作者：
Lee SH
人融合 NKG2D-IL-15 蛋白通过 NK 细胞的招募和激活来控制异种移植人胃癌
影响因子：
24.1
作者：
Chen, Yan;Chen, Bei;Gong, Weijuan
通讯作者：
Gong, Weijuan
影响因子：
2.2
作者：
Norris, Sonia;Coleman, Adam;Goodier, Martin R.
通讯作者：
Goodier, Martin R.