Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise.
Recruitment of the prefrontal cortex and cerebellum in Parkinsonian rats following skilled aerobic exercise.
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DOI：
10.1016/j.nbd.2015.02.020
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发表时间：
2015-05
影响因子：
6.1
通讯作者：
Holschneider, Daniel P.
中科院分区：
文献类型：
--
作者：
Wang, Zhuo;Guo, Yumei;Myers, Kalisa G.;Heintz, Ryan;Holschneider, Daniel P.
关键词：
运动方式和复杂性在决定帕金森病（PD）的神经康复结果中起着关键作用。结合运动技能训练和有氧运动的运动训练（ET）已被提议协同改善PD患者运动控制的认知和自动成分。在这里，我们介绍了这样一个熟练的有氧ET范式在大鼠模型的多巴胺能神经传入阻滞。将双侧纹状体内6-羟基多巴胺损伤的大鼠暴露于强迫ET 4周，无论是在简单的跑步轮上（非熟练有氧运动，NSAE）还是在具有不规则间隔梯级的复杂轮上（熟练有氧运动，SAE）。ET完成后1周，在水平踏车行走或休息时使用[14 C]-碘安替比林绘制脑灌注图。局部脑血流量（rCBF）定量放射自显影和分析的三维重建的大脑统计参数映射。与NSAE相比，SAE导致运动缺陷的恢复相等或更大，以及行走期间前额皮质的边缘前区、躯体感觉皮质的广泛区域和小脑的rCBF增加更大。与SAE动物相比，NSAE在背侧尾壳核和背侧海马中表现出更大的激活。种子相关性分析显示，与NSAE动物相比，SAE动物的前边缘皮层和运动区之间的功能连接增强，以及中线小脑和感觉运动区之间的功能连接改变。我们的研究提供了第一个证据，功能性脑重组后，熟练的有氧运动在帕金森病大鼠，并表明SAE相比，NSAE的结果在增强前额叶皮层和小脑介导的控制运动功能。
Exercise modality and complexity play a key role in determining neurorehabilitative outcome in Parkinson’s disease (PD). Exercise training (ET) that incorporates both motor skill training and aerobic exercise has been proposed to synergistically improve cognitive and automatic components of motor control in PD patients. Here we introduced such a skilled aerobic ET paradigm in a rat model of dopaminergic deafferentation. Rats with bilateral, intra-striatal 6-hydroxydopamine lesions were exposed to forced ET for 4 weeks, either on a simple running wheel (non-skilled aerobic exercise, NSAE) or on a complex wheel with irregularly spaced rungs (skilled aerobic exercise, SAE). Cerebral perfusion was mapped during horizontal treadmill walking or at rest using [14C]-iodoantipyrine 1 week after the completion of ET. Regional cerebral blood flow (rCBF) was quantified by autoradiography and analyzed in 3-dimensionally reconstructed brains by statistical parametric mapping. SAE compared to NSAE resulted in equal or greater recovery in motor deficits, as well as greater increases in rCBF during walking in the prelimbic area of the prefrontal cortex, broad areas of the somatosensory cortex, and the cerebellum. NSAE compared to SAE animals showed greater activation in the dorsal caudate-putamen and dorsal hippocampus. Seed correlation analysis revealed enhanced functional connectivity in SAE compared to NSAE animals between the prelimbic cortex and motor areas, as well as altered functional connectivity between midline cerebellum and sensorimotor regions. Our study provides the first evidence for functional brain reorganization following skilled aerobic exercise in Parkinsonian rats, and suggests that SAE compared to NSAE results in enhancement of prefrontal cortex- and cerebellum-mediated control of motor function.
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DOI：
10.1016/j.apmr.2007.05.015
发表时间：
2007-09-01
影响因子：
4.3
作者：
Herman, Talia;Giladi, Nir;Hausdorff, Jeffrey M.
通讯作者：
Hausdorff, Jeffrey M.
影响因子：
3.8
作者：
CADET, JL;LAST, R;JACKSONLEWIS, V
通讯作者：
JACKSONLEWIS, V
影响因子：
6.2
作者：
ANDERSON, BJ;LI, XC;GREENOUGH, WT
通讯作者：
GREENOUGH, WT
影响因子：
2.5
作者：
Floyer-Lea, A;Matthews, PM
通讯作者：
Matthews, PM
影响因子：
2.9
作者：
Ferreira, Ana F. B.;Real, Caroline C.;Britto, Luiz R. G.
通讯作者：
Britto, Luiz R. G.