Plasmonic nano-antimicrobials: properties, mechanisms and applications in microbe inactivation and sensing.
Plasmonic nano-antimicrobials: properties, mechanisms and applications in microbe inactivation and sensing.
复制标题
等离子体纳米抗菌剂：性质、机理及在微生物灭活和传感中的应用。
DOI：
10.1039/d0nr08353d
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发表时间：
2021-02-14
期刊：
影响因子：
6.7
通讯作者：
Reinhard BM
中科院分区：
文献类型：
--
作者：
An X;Erramilli S;Reinhard BM
细菌、病毒和真菌感染对人类健康和福祉构成严重威胁。病原微生物引起的急性传染病的不断出现以及对传统抗菌药物耐药性的迅速发展，需要制定新的有效策略来安全消除水、食物或表面上的微生物，以及灭活人类宿主中的病原微生物。对新型抗菌剂的需求引发了等离激元纳米抗菌剂的开发，该抗菌剂可促进光依赖性和非光依赖性微生物灭活机制。本综述介绍了这些等离子体纳米抗菌剂的相关光物理机制，并概述了等离子体纳米结构的光响应和材料特性如何应用于微生物病原体灭活和传感应用。通过对不同等离子体纳米结构的灭活功效的系统分析，该综述概述了等离子体纳米抗菌剂的最新技术，并界定了不同微生物灭活策略的应用空间。等离子体纳米抗菌剂的有利光学特性还增强了微生物检测和传感方式，从而有助于避免暴露于微生物病原体。讨论了灵敏和快速的等离子体微生物传感方式及其治疗诊断和靶向治疗应用。
Bacterial, viral and fungal infections pose serious threats to human health and well-being. The continuous emergence of acute infectious diseases caused by pathogenic microbes and the rapid development of resistances against conventional antimicrobial drugs necessitates the development of new and effective strategies for the safe elimination of microbes in water, food or on surfaces, as well as for the inactivation of pathogenic microbes in human hosts. The need for new antimicrobials has triggered the development of plasmonic nano-antimicrobials that facilitate both light-dependent and - independent microbe inactivation mechanisms. This review introduces the relevant photophysical mechanisms underlying these plasmonic nano-antimicrobials, and provides an overview of how the photoresponses and materials properties of plasmonic nanostructures can be applied in microbial pathogen inactivation and sensing applications. Through a systematic analysis of the inactivation efficacies of different plasmonic nanostructures, this review outlines the current state-of-the-art in plasmonic nano-antimicrobials and defines the application space for different microbial inactivation strategies. The advantageous optical properties of plasmonic nano-antimicrobials also enhance microbial detection and sensing modalities and thus help to avoid exposure to microbial pathogens. Sensitive and fast plasmonic microbial sensing modalities and their theranostic and targeted therapeutic applications are discussed.
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DOI：
10.1021/jp900874n
发表时间：
2009-06-08
期刊：
The journal of physical chemistry. C, Nanomaterials and interfaces
影响因子：
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作者：
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Reinhard BM
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DOI：
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发表时间：
2014
期刊：
Plasmonics (Norwell, Mass.)
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Dostalek J
DOI：
10.1016/j.jphotochem.2018.11.001
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2019-03-15
影响因子：
4.3
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DOI：
10.3390/s17112569
发表时间：
2017-11-07
期刊：
Sensors (Basel, Switzerland)
影响因子：
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Ashiba H;Iizumi Y;Okazaki T;Wang X;Fujimaki M
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Fujimaki M