Degradation of connexins and gap junctions.
Degradation of connexins and gap junctions.
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DOI:
10.1016/j.febslet.2014.01.031
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发表时间:
2014-04-17
期刊:
影响因子:
3.5
通讯作者:
Berthoud VM
中科院分区:
文献类型:
--
作者:
Falk MM;Kells RM;Berthoud VM
Connexin proteins are short-lived within the cell, whether present in the secretory pathway or in gap junction plaques. Their levels can be modulated by their rate of degradation. Connexins, at different stages of assembly, are degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways. In this review, we summarize the current knowledge about connexin and gap junction degradation including the signals and protein-protein interactions that participate in their targeting for degradation.
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