A unique RPW8-encoding class of genes that originated in early land plants and evolved through domain fission, fusion, and duplication.
A unique RPW8-encoding class of genes that originated in early land plants and evolved through domain fission, fusion, and duplication.
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DOI：
10.1038/srep32923
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发表时间：
2016-09-28
影响因子：
4.6
通讯作者：
Cheng ZM
中科院分区：
文献类型：
--
作者：
Zhong Y;Cheng ZM
复制、横向基因转移、结构域融合/分裂和从头结构域创建在最初共同祖先蛋白的形成中起关键作用。丰富的蛋白质二聚体是由结构域重排产生的，包括融合、分裂、复制和末端结构域丢失。在这份报告中，我们探讨了RPW 8结构域的起源，并检查了驱动陆地植物中RPW 8编码基因进化的结构域重排。RPW 8结构域首先出现在早期陆地植物小立碗藓中，并且它可能从头起源于非编码序列或复制后的结构域分歧。然后将其整合到NBS-LRR蛋白中，以创建RPW 8编码基因的主要子类，即RPW 8-NBS-encoding gene。它们是通过一系列领域分裂、融合和复制的遗传事件进化而来的。许多种特异性重复事件和串联重复簇清楚地表明，种特异性和串联重复在RPW 8编码基因的扩增中起着重要作用，特别是在裸子植物和蔷薇科植物中。RPW 8结构域的Ka/Ks值比NBS结构域的Ka/Ks值大，表明它们在RPW 8-NBS中的进化速度比NBS结构域快。
Duplication, lateral gene transfer, domain fusion/fission and de novo domain creation play a key role in formation of initial common ancestral protein. Abundant protein diversities are produced by domain rearrangements, including fusions, fissions, duplications, and terminal domain losses. In this report, we explored the origin of the RPW8 domain and examined the domain rearrangements that have driven the evolution of RPW8-encoding genes in land plants. The RPW8 domain first emerged in the early land plant, Physcomitrella patens, and it likely originated de novo from a non-coding sequence or domain divergence after duplication. It was then incorporated into the NBS-LRR protein to create a main sub-class of RPW8-encoding genes, the RPW8-NBS-encoding genes. They evolved by a series of genetic events of domain fissions, fusions, and duplications. Many species-specific duplication events and tandemly duplicated clusters clearly demonstrated that species-specific and tandem duplications played important roles in expansion of RPW8-encoding genes, especially in gymnosperms and species of the Rosaceae. RPW8 domains with greater Ka/Ks values than those of the NBS domains indicated that they evolved faster than the NBS domains in RPW8-NBSs.
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影响因子：
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作者：
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影响因子：
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DOI：
10.1126/science.1197761
发表时间：
2011-02-04
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Boore JL