Association between Cardiac Autonomic Neuropathy and Coronary Artery Lesions in Patients with Type 2 Diabetes.
Association between Cardiac Autonomic Neuropathy and Coronary Artery Lesions in Patients with Type 2 Diabetes.
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DOI：
10.1155/2020/6659166
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Liu L;Wu Q;Yan H;Chen B;Zheng X;Zhou Q
心脏自主神经病变（CAN）是糖尿病常见的严重并发症，可累及全身，如动脉粥样硬化性心血管疾病。我们的目的是评估CAN和2型糖尿病患者冠状动脉病变之间的关系。研究设计和方法。回顾性分析104例2型糖尿病合并冠心病患者的临床资料。我们评估了心率变异性（HRV）参数（SDANN，SDNN和pNN 50），以评估心脏自主神经功能。冠状动脉病变的严重程度通过Gensini评分和受累血管的数量进行评估。将HRV参数与冠状动脉病变程度及临床参数进行相关分析。 斯皮尔曼相关分析显示，SDANN与Gensini评分之间存在显著负相关（r =-0.22，P = 0.03）。有趣的是，在调整临床协变量后，这一发现仍然显著（r =-0.23，P = 0.03）。然而，心率变异性参数和冠状动脉病变的严重程度之间没有相关性，如受影响的血管数量所评估的。临床参数与HRV参数无显著相关性（均P > 0.05）。 心脏自主神经病变可能与2型糖尿病患者冠状动脉粥样硬化程度有关。心脏自主神经病变的筛查可能对2型糖尿病患者的危险分层有益。
Cardiac autonomic neuropathy (CAN) is a common and serious complication of diabetes mellitus with various systemic involvements, such as atherosclerotic cardiovascular disease. We aimed to evaluate the association between CAN and coronary artery lesions in patients with type 2 diabetes. Research Design and Methods. We retrospectively reviewed the medical records of 104 patients with type 2 diabetes and coronary artery disease (CAD). We evaluated heart rate variability (HRV) parameters (SDANN, SDNN, and pNN50) to assess cardiac autonomic function. The severity of coronary lesions was assessed by the Gensini scores and the number of affected vessels. Correlation analyses between HRV parameters and the severity of coronary lesions and clinical parameters were performed. Spearman's correlation analysis showed a significant negative correlation between SDANN and Gensini scores (r = −0.22, P = 0.03). Interestingly, this finding remained significant after adjusting for clinical covariates (r = −0.23, P = 0.03). However, there was no association between HRV parameters and the severity of coronary lesions as assessed by the number of affected vessels. Clinical parameters were not significantly correlated with HRV parameters (all P > 0.05). Cardiac autonomic neuropathy might be related to the degree of coronary atheromatous burden in patients with type 2 diabetes. Screening for cardiac autonomic neuropathy might potentially be beneficial in the risk stratification of patients with type 2 diabetes.
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DOI：
10.1177/0300060518778416
发表时间：
2018-09
期刊：
The Journal of international medical research
影响因子：
--
作者：
Chen Y;Yu Y;Zou W;Zhang M;Wang Y;Gu Y
通讯作者：
Gu Y
影响因子：
2.8
作者：
Bhati, Pooja;Alam, Rizwan;Hussain, M. Ejaz
通讯作者：
Hussain, M. Ejaz
影响因子：
2.8
作者：
Didangelos, Triantafyllos P.;Arsos, Georgios;Athyros, Vasilios
通讯作者：
Athyros, Vasilios
影响因子：
0.6
作者：
Mendo, D. S.;Gonzalez, S. A.;Bonaccorsi, H. A.
通讯作者：
Bonaccorsi, H. A.
影响因子：
5.8
作者：
Nattero-Chavez, Lia;Redondo Lopez, Sandra;Luque-Ramirez, Manuel
通讯作者：
Luque-Ramirez, Manuel