An oscillatory mechanism for multi-level storage in short-term memory.
An oscillatory mechanism for multi-level storage in short-term memory.
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DOI：
10.1038/s42003-023-05200-7
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发表时间：
2023-08-10
影响因子：
5.9
通讯作者：
Goldman, Mark S.
中科院分区：
文献类型：
--
作者：
Champion, Kathleen P.;Gozel, Olivia;Lankow, Benjamin S.;Ermentrout, G. Bard;Goldman, Mark S.
Oscillatory activity is commonly observed during the maintenance of information in short-term memory, but its role remains unclear. Non-oscillatory models of short-term memory storage are able to encode stimulus identity through their spatial patterns of activity, but are typically limited to either an all-or-none representation of stimulus amplitude or exhibit a biologically implausible exact-tuning condition. Here we demonstrate a simple mechanism by which oscillatory input enables a circuit to generate persistent or sequential activity that encodes information not only in the spatial pattern of activity, but also in the amplitude of activity. This is accomplished through a phase-locking phenomenon that permits many different amplitudes of persistent activity to be stored without requiring exact tuning of model parameters. Altogether, this work proposes a class of models for the storage of information in working memory, a potential role for brain oscillations, and a dynamical mechanism for maintaining multi-stable neural representations. Computational modeling shows how adding oscillatory inputs to a working memory network can lead to more robust persistent activity, while limiting issues observed in previous models.
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影响因子：
3
作者：
Hoffman KL;Dragan MC;Leonard TK;Micheli C;Montefusco-Siegmund R;Valiante TA
通讯作者：
Valiante TA
θ-γ神经代码。
影响因子：
16.2
作者：
Lisman JE;Jensen O
通讯作者：
Jensen O
DOI：
10.1073/pnas.1302351110
发表时间：
2013-08-06
影响因子：
11.1
作者：
Jutras, Michael J.;Fries, Pascal;Buffalo, Elizabeth A.
通讯作者：
Buffalo, Elizabeth A.
DOI：
10.1073/pnas.0809511105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Borgers, Christoph;Epstein, Steven;Kopell, Nancy J.
通讯作者：
Kopell, Nancy J.
影响因子：
56.9
作者：
LISMAN, JE;IDIART, MAP
通讯作者：
IDIART, MAP