Consolidation and translation regulation.
Consolidation and translation regulation.
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DOI：
10.1101/lm.026849.112
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发表时间：
2012-08-16
期刊：
影响因子：
--
通讯作者：
Rosenblum K
中科院分区：
文献类型：
--
作者：
Gal-Ben-Ari S;Kenney JW;Ounalla-Saad H;Taha E;David O;Levitan D;Gildish I;Panja D;Pai B;Wibrand K;Simpson TI;Proud CG;Bramham CR;Armstrong JD;Rosenblum K
信使核糖核酸的翻译，或蛋白质的合成，是遗传密码转化为任何细胞活动的主要组成部分。这个复杂的、多步骤的过程分为三个阶段：启动、延伸和终止。起始是核糖体被招募到信使核糖核酸的步骤，被认为是翻译中的主要限速步骤，而伸长包括多肽链的延长；这两个步骤都是经常调节的目标，这被定义为单位时间内信使核糖体翻译速率的变化。在正常大脑中，翻译控制是调节记忆和突触可塑性巩固的关键机制，即对获得性信息的离线处理。这些调节过程可能在不同的大脑结构或神经元群体中有所不同。此外，翻译的失调会导致大脑的病理性功能，如记忆障碍。翻译机制的正常和异常功能都被认为会导致mRNAs子集的翻译上调或下调。然而，鉴定这些新合成的蛋白质，以及确定不同神经元类型和不同脑区在不同时间点发生的蛋白质合成或降解速率，需要新的蛋白质组学方法和系统生物学手段。在这里，我们详细讨论翻译调控与记忆或突触可塑性巩固的关系，同时重点讨论皮层依赖的味觉学习任务和海马区依赖的可塑性的模型。此外，我们描述了一个新的系统生物学角度来更好地描述合并。
mRNA translation, or protein synthesis, is a major component of the transformation of the genetic code into any cellular activity. This complicated, multistep process is divided into three phases: initiation, elongation, and termination. Initiation is the step at which the ribosome is recruited to the mRNA, and is regarded as the major rate-limiting step in translation, while elongation consists of the elongation of the polypeptide chain; both steps are frequent targets for regulation, which is defined as a change in the rate of translation of an mRNA per unit time. In the normal brain, control of translation is a key mechanism for regulation of memory and synaptic plasticity consolidation, i.e., the off-line processing of acquired information. These regulation processes may differ between different brain structures or neuronal populations. Moreover, dysregulation of translation leads to pathological brain function such as memory impairment. Both normal and abnormal function of the translation machinery is believed to lead to translational up-regulation or down-regulation of a subset of mRNAs. However, the identification of these newly synthesized proteins and determination of the rates of protein synthesis or degradation taking place in different neuronal types and compartments at different time points in the brain demand new proteomic methods and system biology approaches. Here, we discuss in detail the relationship between translation regulation and memory or synaptic plasticity consolidation while focusing on a model of cortical-dependent taste learning task and hippocampal-dependent plasticity. In addition, we describe a novel systems biology perspective to better describe consolidation.
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影响因子：
64.8
作者：
Autry, Anita E.;Adachi, Megunai;Nosyreva, Elena;Na, Elisa S.;Los, Maarten F.;Cheng, Peng-fei;Kavalali, Ege T.;Monteggia, Lisa M.
通讯作者：
Monteggia, Lisa M.
影响因子：
16
作者：
Bidinosti M;Ran I;Sanchez-Carbente MR;Martineau Y;Gingras AC;Gkogkas C;Raught B;Bramham CR;Sossin WS;Costa-Mattioli M;DesGroseillers L;Lacaille JC;Sonenberg N
通讯作者：
Sonenberg N
影响因子：
5.3
作者：
Banko, JL;Poulin, F;Klann, E
通讯作者：
Klann, E
影响因子：
5.3
作者：
Barki-Harrington, Liza;Elkobi, Alina;Rosenblum, Kobi
通讯作者：
Rosenblum, Kobi
影响因子：
3.7
作者：
Bekinschtein, Pedro;Katche, Cynthia;Medina, Jorge H.
通讯作者：
Medina, Jorge H.