Associations between Optic Nerve Head-Related Anatomical Parameters and Refractive Error over the Full Range of Glaucoma Severity.
Associations between Optic Nerve Head-Related Anatomical Parameters and Refractive Error over the Full Range of Glaucoma Severity.
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DOI：
10.1167/tvst.6.4.9
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发表时间：
2017-07
影响因子：
3
通讯作者：
Elze T
中科院分区：
文献类型：
--
作者：
Baniasadi N;Wang M;Wang H;Mahd M;Elze T
评价视盘（OD）相关解剖参数之间的相关性（上级和下颞视网膜动脉之间的动脉间角[IAA]，OD倾斜[TL]、旋转[ROT]和扭转[TO]，OD表面曲率[CUR]和OD上的中央视网膜血管主干入口点位置[CRIT]）和屈光不正的等效球镜（SE），并评估青光眼严重程度对这些关系的影响。包括438例患者的Cirrus光学相干断层扫描（OCT）眼底图像和24-2视野。将椭圆拟合到OD边界。在OD周围的圆圈上标记的视网膜动脉位置之间计算IAA。在OD上标记血管入口点以定位CRYPE。TL测量为拟合OD临床边界的线与水平B扫描上的Bruch膜边缘之间的角度。相对于垂直轴的椭圆旋转定义为ROT。OD长轴与TO定义的动脉间线之间的角度。CUR由水平B超上的内界膜确定。使用贝叶斯因子（BF）评价的线性回归模型确定参数和SE之间的协方差结构以及平均偏差（MD）的可能影响。结果表明，与SE相关性最强的是CRYSTAL，其次是ROT、TL和IAA（BFs分别为3.59 × 107、2645、1126和248）。MD没有显著调节ONH参数和SE之间的关系。我们的研究结果表明，SE时，应考虑解释OD和其周围的乳头状区域的诊断目的。OD相关参数与屈光不正之间的关系可能有助于减少视神经病变的假阳性临床诊断。
To evaluate the associations between optic disc (OD)-related anatomical parameters (interartery angle [IAA] between superior and inferior temporal retinal arteries, OD tilt [TL], rotation [ROT], and torsion [TO], OD surface curvature [CUR], and central retinal vessel trunk entry point location [CRVTL] on OD) and the spherical equivalent of refractive error (SE), and to assess the impact of glaucoma severity on these relationships. Cirrus optical coherence tomography (OCT) fundus images and 24-2 visual fields of 438 patients were included. Ellipses were fitted to OD borders. IAA was calculated between marked retinal artery locations on a circle around OD. Blood vessel entry point on OD was marked to locate CRVTL. TL was measured as the angle between the lines fitted to OD clinical boundary and the Bruch's membrane edges on the horizontal B-scans. Ellipse rotation relative to the vertical axis defined ROT. Angle between the long axis of OD and the interartery line defined TO. CUR was determined by the inner limiting membrane on the horizontal B-scans. Linear regression models evaluated by Bayes Factors (BF) were used to determine the covariance structure between the parameters and SE as well as possible impacts of mean deviation (MD). Our results showed that CRVTL had the strongest relationship with SE, followed by ROT, TL, and IAA (BFs: 3.59 × 107, 2645, 1126, and 248, respectively). MD did not significantly modulate the relationship between ONH parameters and SE. Our results suggest that SE should be considered when interpreting the OD and its circumpapillary region for diagnostic purposes. The reported relationships between OD-related parameters and ametropia may help to decrease false-positive clinical diagnoses of optic neuropathies.
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影响因子：
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