Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine.
Quantity of Vaccine Poliovirus Shed Determines the Titer of the Serum Neutralizing Antibody Response in Indian Children Who Received Oral Vaccine.
复制标题
DOI：
10.1093/infdis/jix687
复制
发表时间：
2018-04-11
期刊：
影响因子：
--
通讯作者：
Kang G
中科院分区：
文献类型：
--
作者：
Giri S;Kumar N;Dhanapal P;Venkatesan J;Kasirajan A;Iturriza-Gomara M;John J;Abraham AM;Grassly NC;Kang G
口服脊髓灰质炎病毒疫苗（OPV）在肠道内的复制（即疫苗接种）与血清转化和预防脊髓灰质炎有关。我们使用定量聚合酶链反应分析，以衡量疫苗脱落300名6-11个月龄的血清阴性婴儿和218名1-4岁的儿童7天后，单价或双价口服脊髓灰质炎疫苗。我们发现，脱落的数量与接种后21或28天测量的血清中和抗体应答的幅度相关。这表明，对口服脊髓灰质炎疫苗的免疫应答是一个连续的过程，而不是一个全有或全无的现象，这取决于有效的疫苗病毒复制。这项涉及印度500名以上5岁以下儿童的研究表明，口服脊髓灰质炎病毒疫苗接种后疫苗病毒脱落的数量与随后产生的血清中和抗体的大小呈正相关。
Replication of oral poliovirus vaccine (OPV) in the intestine (ie, vaccine take) is associated with seroconversion and protection against poliomyelitis. We used quantitative polymerase chain reaction analysis to measure vaccine shedding in 300 seronegative infants aged 6–11 months and in 218 children aged 1–4 years 7 days after administration of monovalent or bivalent OPV. We found that the quantity of shedding correlated with the magnitude of the serum neutralizing antibody response measured 21 or 28 days after vaccination. This suggests that the immune response to OPV is on a continuum, rather than an all-or-nothing phenomenon, that depends on efficient vaccine virus replication. This study involving >500 children <5 years of age from India showed that the quantity of vaccine virus shed after administration of oral poliovirus vaccine is positively correlated with the magnitude of serum neutralizing antibodies developed subsequently.
登录
查看更多内容
影响因子：
5
作者：
JOHN, TJ;CHRISTOPHER, S
通讯作者：
CHRISTOPHER, S
影响因子：
5.4
作者：
Wahid, R;Cannon, MJ;Chow, M
通讯作者：
Chow, M
影响因子：
5.5
作者：
Kaliappan, Saravanakumar Puthupalayam;Venugopal, Srinivasan;Kang, Gagandeep
通讯作者：
Kang, Gagandeep
影响因子：
6.7
作者：
Hird TR;Grassly NC
通讯作者：
Grassly NC
影响因子：
158.5
作者：
Galindo, Miguel;Lago, Pedro Mas;Sutter, Roland
通讯作者：
Sutter, Roland