Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge.
Systematic review of mucosal immunity induced by oral and inactivated poliovirus vaccines against virus shedding following oral poliovirus challenge.
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DOI：
10.1371/journal.ppat.1002599
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发表时间：
2012
期刊：
影响因子：
6.7
通讯作者：
Grassly NC
中科院分区：
文献类型：
--
作者：
Hird TR;Grassly NC
灭活脊髓灰质炎病毒疫苗（IPV）可用于消灭脊髓灰质炎最后阶段的大规模疫苗接种活动。在根除脊髓灰质炎病毒后，全球协调停止口服脊髓灰质炎疫苗（OPV）接种后，许多国家也可能采用该方案。IPV在控制脊髓灰质炎暴发方面的成功将取决于诱导的针对脊髓灰质炎病毒感染的鼻咽和肠粘膜免疫的程度。我们对截至2011年5月发表的研究进行了系统回顾，这些研究记录了OPV“挑战”剂量后5-30天收集的粪便样本或鼻咽分泌物中脊髓灰质炎病毒脱落的流行率。在根据IPV、OPV和联合方案接种疫苗的儿童中，将研究合并在脱落几率的荟萃分析中。我们确定了31项粪便脱落研究和4项鼻咽样本脱落研究符合纳入标准。与未接种疫苗的个体相比，接种OPV疫苗的个体在攻毒后采集的粪便样本中可预防脊髓灰质炎病毒感染和脱落（脱落的汇总比值比[OR]为0.13（95%置信区间[CI] 0.08-0.24））。相比之下，与未接种疫苗的个体相比（总结OR 0.81 [95% CI 0.59-1.11]）或与OPV联合给药时与OPV单独给药的个体相比（总结OR 1.14 [95% CI 0.82-1.58]），IPV未提供针对散毒的保护。没有足够的鼻咽脱落研究来得出结论。IPV不能诱导足够的肠粘膜免疫来减少攻毒后粪便脊髓灰质炎病毒脱落的流行，尽管有一些证据表明它可以减少病毒脱落的数量。在粪-口传播常见的国家，IPV对脊髓灰质炎病毒传播的影响尚不清楚，但与OPV相比可能有限。
Inactivated poliovirus vaccine (IPV) may be used in mass vaccination campaigns during the final stages of polio eradication. It is also likely to be adopted by many countries following the coordinated global cessation of vaccination with oral poliovirus vaccine (OPV) after eradication. The success of IPV in the control of poliomyelitis outbreaks will depend on the degree of nasopharyngeal and intestinal mucosal immunity induced against poliovirus infection. We performed a systematic review of studies published through May 2011 that recorded the prevalence of poliovirus shedding in stool samples or nasopharyngeal secretions collected 5–30 days after a “challenge” dose of OPV. Studies were combined in a meta-analysis of the odds of shedding among children vaccinated according to IPV, OPV, and combination schedules. We identified 31 studies of shedding in stool and four in nasopharyngeal samples that met the inclusion criteria. Individuals vaccinated with OPV were protected against infection and shedding of poliovirus in stool samples collected after challenge compared with unvaccinated individuals (summary odds ratio [OR] for shedding 0.13 (95% confidence interval [CI] 0.08–0.24)). In contrast, IPV provided no protection against shedding compared with unvaccinated individuals (summary OR 0.81 [95% CI 0.59–1.11]) or when given in addition to OPV, compared with individuals given OPV alone (summary OR 1.14 [95% CI 0.82–1.58]). There were insufficient studies of nasopharyngeal shedding to draw a conclusion. IPV does not induce sufficient intestinal mucosal immunity to reduce the prevalence of fecal poliovirus shedding after challenge, although there was some evidence that it can reduce the quantity of virus shed. The impact of IPV on poliovirus transmission in countries where fecal-oral spread is common is unknown but is likely to be limited compared with OPV.
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影响因子：
0.6
作者：
ENDERSRUCKLE, G;SIEGERT, R
通讯作者：
SIEGERT, R
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
--
作者：
MARINE, WM;GRAVELLE, CR;CHIN, TDY
通讯作者：
CHIN, TDY
影响因子：
5.5
作者：
du Châtelet, IP;Merchant, AT;Mc Cormick, JB
通讯作者：
Mc Cormick, JB
影响因子：
3.8
作者：
Krieg, C;Maier, R;Meyerhans, A
通讯作者：
Meyerhans, A