Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression.
Dissociable patterns of abnormal frontal cortical activation during anticipation of an uncertain reward or loss in bipolar versus major depression.
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DOI：
10.1111/bdi.12132
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发表时间：
2013-12
影响因子：
5.4
通讯作者：
Phillips ML
中科院分区：
文献类型：
--
作者：
Chase HW;Nusslock R;Almeida JR;Forbes EE;LaBarbara EJ;Phillips ML
最近的研究发现，在双相情感障碍（BD）的奖励相关的神经激活异常，在躁狂和心境正常阶段。然而，奖励相关的神经激活在目前抑郁的个人与BD和目前抑郁的个人与重性抑郁症（MDD）尚未直接比较。在这里，我们研究了这些群体，检查在猜测任务中引起的神经激活在额纹状体区域确定以前的研究。我们在两组抑郁症患者中使用fMRI评估了奖励任务期间的神经激活，一组为双相I型障碍（BD-I）（n = 23），一组为MDD（n = 40），疾病严重程度相似，另一组为健康个体（n = 37）。在健康个体中观察到前扣带皮层中与奖励期望相关的激活，但在抑郁患者中（BD-I和MDD一起）显着减少。与其他两组相比，BD-I抑郁组的左腹外侧前额叶皮层的预期相关激活增加。在三组中，腹侧纹状体的预测错误相关激活没有显著差异。这些发现扩展了先前的研究，该研究已经确定了BD中腹外侧前额叶皮层的功能障碍，并表明在预期奖励或损失期间该区域的异常升高的活动可能会区分患有BD-I的抑郁个体与患有MDD的个体。前扣带皮层在奖励期望过程中的激活改变是两种抑郁症的特征。这些发现对识别BD-I和MDD神经回路的共同和不同特性具有重要意义。
Recent research has found abnormalities in reward-related neural activation in bipolar disorder (BD), during both manic and euthymic phases. However, reward-related neural activation in currently depressed individuals with BD and that in currently depressed individuals with major depressive disorder (MDD) have yet to be directly compared. Here, we studied these groups, examining the neural activation elicited during a guessing task in fronto-striatal regions identified by previous studies. We evaluated neural activation during a reward task using fMRI in two groups of depressed individuals, one with bipolar I disorder (BD-I) (n = 23) and one with MDD (n = 40), with similar levels of illness severity, and a group of healthy individuals (n = 37). Reward expectancy-related activation in the anterior cingulate cortex was observed in the healthy individuals, but was significantly reduced in depressed patients (BD-I and MDD together). Anticipation-related activation was increased in the left ventrolateral prefrontal cortex in the BD-I depressed group compared with the other two groups. There were no significant differences in prediction error-related activation in the ventral striatum across the three groups. The findings extend previous research which has identified dysfunction within the ventrolateral prefrontal cortex in BD, and show that abnormally elevated activity in this region during anticipation of either reward or loss may distinguish depressed individuals with BD-I from those with MDD. Altered activation of the anterior cingulate cortex during reward expectancy characterizes both types of depression. These findings have important implications for identifying both common and distinct properties of the neural circuitry underlying BD-I and MDD.
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影响因子：
5.7
作者：
Foland-Ross LC;Bookheimer SY;Lieberman MD;Sugar CA;Townsend JD;Fischer J;Torrisi S;Penfold C;Madsen SK;Thompson PM;Altshuler LL
通讯作者：
Altshuler LL
影响因子：
--
作者：
Blumberg, HP;Leung, HC;Peterson, BS
通讯作者：
Peterson, BS
影响因子：
2.6
作者：
Diekhof, Esther Kristina;Kaps, Lisa;Gruber, Oliver
通讯作者：
Gruber, Oliver
影响因子：
3.4
作者：
Abler, Birgit;Erk, Susanne;Walter, Henrik
通讯作者：
Walter, Henrik
DOI：
10.1523/jneurosci.3864-11.2012
发表时间：
2012-03-14
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cai X;Padoa-Schioppa C
通讯作者：
Padoa-Schioppa C