A macrophage relay for long-distance signaling during postembryonic tissue remodeling
A macrophage relay for long-distance signaling during postembryonic tissue remodeling
复制标题
胚胎后组织重塑过程中长距离信号传导的巨噬细胞中继
作者：
D. Eom;D. Parichy
巨噬细胞投射参与斑马鱼条纹形成过程中色素细胞间的长程信号传递。细胞投影建立色素模式Macrophages消除死亡或垂死的细胞，识别和摧毁入侵的微生物。然而，它们在发育和稳态中也表现出非免疫功能。Eom和Parichy表明，巨噬细胞在斑马鱼成年色素条纹形成过程中对胚后重塑至关重要（参见Guilliams的观点）。色素细胞通过细胞投射将含有信号的囊泡从一类细胞传递到另一类细胞。没有巨噬细胞，这种信号传递失败，成年条纹是混乱的。《科学》，本期第1317页;另见第1258页，巨噬细胞在免疫、发育和体内平衡中具有多种功能。我们确定了这些细胞在胚后组织重塑过程中进行长距离通信的功能。消融斑马鱼巨噬细胞阻止黑色素细胞合并成成年色素条纹。黑素细胞的组织依赖于黄色黄色素细胞系通过气丝（airinemes）提供的信号，气丝是尖端有囊泡的长丝状突起。我们表明，airineme延伸从起源细胞，以及囊泡沉积在靶细胞，依赖于与巨噬细胞的相互作用。这些发现确定了巨噬细胞在非免疫细胞之间传递远程信号的作用。这种信号传导方式可能在正常发育和疾病期间在其他组织的重塑和稳态中起作用。
Macrophage projections participate in long-range signaling between pigment cells during zebrafish stripe formation. Cell projections set up pigment pattern Macrophages eliminate dead or dying cells and identify and destroy invading microbes. However, they also exhibit nonimmune functions in development and homeostasis. Eom and Parichy show that macrophages are essential for postembryonic remodeling during adult pigment stripe formation in zebrafish (see the Perspective by Guilliams). Pigment cells relay signal-containing vesicles via cellular projections from one class of cell to another. Without macrophages, this signal relay fails, and adult stripes are disorganized. Science, this issue p. 1317; see also p. 1258 Macrophages have diverse functions in immunity as well as in development and homeostasis. We identified a function for these cells in long-distance communication during postembryonic tissue remodeling. Ablation of macrophages in zebrafish prevented melanophores from coalescing into adult pigment stripes. Melanophore organization depends on signals provided by cells of the yellow xanthophore lineage via airinemes, long filamentous projections with vesicles at their tips. We show that airineme extension from originating cells, as well as vesicle deposition on target cells, depend on interactions with macrophages. These findings identify a role for macrophages in relaying long-range signals between nonimmune cells. This signaling modality may function in the remodeling and homeostasis of other tissues during normal development and disease.
影响因子：
7.2
作者：
Hochreiter-Hufford, Amelia;Ravichandran, Kodi S.
通讯作者：
Ravichandran, Kodi S.
影响因子：
13.6
作者：
Stefater JA 3rd;Ren S;Lang RA;Duffield JS
通讯作者：
Duffield JS
影响因子：
4.6
作者：
D. Parichy;D. Ransom;B. Paw;Len I Zon;Stephen L. Johnson
通讯作者：
D. Parichy;D. Ransom;B. Paw;Len I Zon;Stephen L. Johnson