Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.
Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines.
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DOI：
10.1021/acs.inorgchem.7b02747
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发表时间：
2018-02-05
影响因子：
4.6
通讯作者：
Wilson JJ
中科院分区：
文献类型：
--
作者：
Marker SC;MacMillan SN;Zipfel WR;Li Z;Ford PC;Wilson JJ
十五种通式[Re（CO）3（NN）（PR 3）]+的水溶性双金属化合物，其中NN是二亚胺配体，PR 3是1，3，5-三氮杂-7-磷杂金刚烷（PTA）、三氮杂-7-磷杂金刚烷（PR 3）或它们的混合物，合成了1，4-二乙酰基-1，3，7-三氮杂-5-磷杂双环[3.3.1]壬烷（DAPTA），并通过多核NMR，IR，和X射线晶体学带有THP和DAPTA配体的配合物在空气平衡的水溶液中表现出基于三重态的发光，量子产率范围为3.4%至11.5%。此外，THP和DAPTA复合物在用365 nm光照射时经历CO配体的光取代，量子产率范围为1.1至5.5%，并且敏化1 O2的形成，量子产率高达70%。相比之下，所有带有PTA配体的络合物都是非发射性的，并且当用365 nm光照射时不发生光取代。这些化合物在人宫颈癌（HeLa）、卵巢癌（A2780）和顺铂耐药卵巢癌（A2780 CP 70）细胞系中作为光活化抗癌剂进行了评价。所有的配合物轴承THP和DAPTA表现出细胞毒性反应后，照射在没有光的情况下具有最小的毒性。值得注意的是，与DAPTA和1，10-菲咯啉的复合物在照射后在HeLa细胞中产生6 μM的IC 50值，使其成为该文库中最具光毒性的化合物。进一步详细探讨了该化合物的光诱导细胞毒性的性质。这些数据表明，光毒性反应可能是由于CO和含铯的光产物的释放，以及1 O2的生产。合成并表征了15个含水溶性膦配体的双（I）三羰基配合物。对这些化合物的详细的光物理研究表明，它们发生光取代反应，并以依赖于轴向膦配体的性质的方式光致发光。基于它们的物理化学性质，这些配合物被评价为宫颈癌和卵巢癌细胞系中的光活化抗癌剂。
Fifteen water-soluble rhenium compounds of the general formula [Re(CO)3(NN)(PR3)]+, where NN is a diimine ligand and PR3 is either 1,3,5-triaza-7-phosphaadamantane (PTA), tris(hydroxymethyl)phosphine (THP), or 1,4-diacetyl-1,3,7-triaza-5-phosphabicylco[3.3.1]nonane (DAPTA), were synthesized and characterized by multinuclear NMR spectroscopy, IR spectroscopy, and X-ray crystallography. The complexes bearing the THP and DAPTA ligands exhibit triplet-based luminescence in air-equilibrated aqueous solutions with quantum yields ranging from 3.4 to 11.5%. Furthermore, the THP and DAPTA complexes undergo photosubstitution of a CO ligand when irradiated with 365 nm light with quantum yields ranging from 1.1 to 5.5% and sensitize the formation of 1O2 with quantum yields as high as 70%. By contrast, all of the complexes bearing the PTA ligand are non-emissive and do not undergo photosubstitution when irradiated with 365 nm light. These compounds were evaluated as photoactivated anticancer agents in human cervical (HeLa), ovarian (A2780), and cisplatin-resistant ovarian (A2780CP70) cancer cell lines. All of the complexes bearing THP and DAPTA exhibited a cytotoxic response upon irradiation with minimal toxicity in the absence of light. Notably, the complex with DAPTA and 1,10-phenanthroline gave rise to an IC50 value of 6 μM in HeLa cells upon irradiation, rendering it the most phototoxic compound in this library. The nature of the photoinduced cytotoxicity of this compound was explored in further detail. These data indicate that the phototoxic response may result from the release of both CO and the rhenium-containing photoproduct, as well as the production of 1O2. Fifteen rhenium(I) tricarbonyl complexes bearing water-soluble phosphines were synthesized and characterized. Detailed photophysical studies on these compounds reveal that they undergo photosubstitution reactions and are photoluminescent in a manner that depends on the nature of the axial phosphine ligand. Based on their photophysical properties, these complexes were evaluated as photoactivated anticancer agents in cervical and ovarian cancer cell lines.
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影响因子：
20.6
作者：
Alderighi, L;Gans, P;Vacca, A
通讯作者：
Vacca, A
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
4.6
作者：
Chakraborty, Indranil;Carrington, Samantha J.;Mascharak, Pradip K.
通讯作者：
Mascharak, Pradip K.
影响因子：
2.3
作者：
BASOLO, F
通讯作者：
BASOLO, F
DOI：
10.1016/1011-1344(94)07048-2
发表时间：
1994-12-01
影响因子：
5.4
作者：
CHARLESWORTH, P;TRUSCOTT, TG;WILSON, BC
通讯作者：
WILSON, BC