Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene.
Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene.
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与NOS1AP基因相关的家族性精神分裂症的儿童创伤和遗传因素。
DOI：
10.1016/j.schres.2010.05.021
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发表时间：
2010-08
影响因子：
4.5
通讯作者：
Bassett, Anne S.
中科院分区：
文献类型：
--
作者：
Husted, Janice A.;Ahmed, Rashid;Chow, Eva W. C.;Brzustowicz, Linda M.;Bassett, Anne S.
有一些证据表明，童年的逆境可能与精神分裂症的表现有关，但遗传风险是否会影响这一发现尚不清楚。我们调查了来自24个多病家族的194名受试者的早期创伤病史，在这些家庭中，精神分裂症以前被证明与NOS1AP基因中的一个功能等位基因有关。在精神分裂症受试者(n=79)中，只考虑精神病发作前的事件。采用广义估计方程模型估计优势比(OR)和95%可信区间(CI)。狭义精神分裂症患者比其未发病的家庭成员更易有早期精神创伤史(调整后OR=4.17，95%CI=1.52，11.44)。在调整NOS1AP危险基因(校正OR=3.57，95%CI=1.32，9.65)和精神分裂症母亲或父亲病史(校正OR=3.27，95%CI=1.45，7.38；4.38，95%CI=1.61，11.91)后，结果相似。结果表明，童年创伤与精神分裂症的表达有关，独立于测量的遗传易感性，并可能成为使用遗传变异进行基因环境研究的候选对象。
There is some evidence that childhood adversity may be associated with the expression of schizophrenia but whether genetic risk affects this finding is unknown. We investigated the history of early trauma in 194 subjects from 24 multiply affected families where schizophrenia was previously shown to be associated with a functional allele in the NOS1AP gene. In subjects with schizophrenia (n=79), only events prior to the onset of psychosis were considered. Generalized estimating equation models that adjusted for familial clustering were used to estimate odds ratios (ORs) and 95% confidence intervals (CI). Subjects with narrowly defined schizophrenia were more likely than their unaffected family members to have a history of early trauma (adjusted OR=4.17, 95% CI=1.52, 11.44). The results were similar after adjusting for the NOS1AP risk genotype (adjusted OR=3.57, 95% CI=1.32, 9.65) and for maternal or paternal history of schizophrenia (adjusted ORs=3.27, 95% CI=1.45, 7.38; 4.38, 95% CI=1.61, 11.91, respectively). The results suggest that childhood trauma is associated with expression of schizophrenia independent of measured genetic susceptibility and may be a candidate for gene-environment research using genetic variants.
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