Role of hydrogen in traumatic brain injury: a narrative review.

Role of hydrogen in traumatic brain injury: a narrative review.
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DOI:
10.4103/2045-9912.314331
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发表时间:
2021-07
影响因子:
2.9
通讯作者:
Chen G
Chen G
中科院分区:
其他
文献类型:
--
作者:
Hu HW;Chen ZG;Liu JG;Chen G

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创伤性脑损伤(TBI)是一个严重的全球性公共卫生问题。创伤性脑损伤的幸存者往往遭受长期残疾,这给社会和家庭带来了沉重的负担。遗憾的是,到目前为止,临床实践中还没有针对TBI患者的有效治疗方法。作为一种还原性气体,氢气已被证明在多种脑疾病模型中具有神经保护作用;然而,其在TBI中的疗效仍存在争议。本文将重点介绍氢在TBI实验中的研究成果,阐述其可能的作用机制,并根据我们目前的认识和观点对未来的研究提出展望。
Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice. As a reducing gas, hydrogen has been shown to be neuroprotective in multiple cerebral disease models; however, its efficacy in TBI remains controversial. In this review, we will focus on the results of hydrogen in experimental TBI, elaborate the potential mechanisms, and put forward for future researches based on our current understanding and views.
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