Absent or low rate of adult neurogenesis in the hippocampus of bats (Chiroptera).
Absent or low rate of adult neurogenesis in the hippocampus of bats (Chiroptera).
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DOI：
10.1371/journal.pone.0000455
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发表时间：
2007-05-23
期刊：
影响因子：
3.7
通讯作者：
Lipp HP
中科院分区：
文献类型：
--
作者：
Amrein I;Dechmann DK;Winter Y;Lipp HP
蝙蝠是唯一的飞行哺乳动物，并具有良好的三维空间导航能力。即使蝙蝠的活动范围相对较小，但它们的活动范围也比啮齿类动物大得多，有些物种的长距离迁徙在小型哺乳动物中是独一无二的。神经元的成体增殖，即，啮齿类动物齿状回中的成年神经发生被认为在空间记忆和学习中起重要作用，如损伤研究和空间行为期间活跃的神经元的记录所表明的。假设成年神经发生在海马功能中的作用，人们可能会期望蝙蝠的成年神经发生水平很高，特别是在需要出色空间工作记忆的水果和花蜜蝙蝠中。12个热带蝙蝠物种的齿状回进行了免疫化学检查，使用多种抗体对增殖细胞（Ki-67，MCM 2），迁移和分化的神经元（Doublecortin，NeuroD）的蛋白质。我们的数据显示，海马神经发生在9个物种（Glossophaga soricina，sperellia perspicillata，Phyllostomus discolor，Nycteris macrotis，Nycteris thebaica，独眼蹄蝠，Neoromicia rendalli，几内亚伏翼，和Scotophilus leucogaster）中完全缺乏，而在3个物种（Chaerephon pumila，Mops condylurus和Hipposideros caffer）中，海马神经发生水平较低。虽然不是所有的抗原在所有物种中被识别，在脑室下区和吻侧迁移流中的增殖活性被发现在所有物种中，证实我们的方法用于检测神经发生的适当性。在我们的蝙蝠样本中，成年海马神经发生的小变化没有显示出与系统发育关系，觅食策略，狩猎栖息地或饮食类型的相关性。我们的数据表明，广泛接受的概念，成人神经支持空间能力需要仔细考虑。鉴于蝙蝠惊人的长寿，某些蝙蝠物种可能是比较成年神经发生与其他长寿物种（如猴子和人类）的有用对象，显示成年海马神经发生率较低。
Bats are the only flying mammals and have well developed navigation abilities for 3D-space. Even bats with comparatively small home ranges cover much larger territories than rodents, and long-distance migration by some species is unique among small mammals. Adult proliferation of neurons, i.e., adult neurogenesis, in the dentate gyrus of rodents is thought to play an important role in spatial memory and learning, as indicated by lesion studies and recordings of neurons active during spatial behavior. Assuming a role of adult neurogenesis in hippocampal function, one might expect high levels of adult neurogenesis in bats, particularly among fruit- and nectar-eating bats in need of excellent spatial working memory. The dentate gyrus of 12 tropical bat species was examined immunohistochemically, using multiple antibodies against proteins specific for proliferating cells (Ki-67, MCM2), and migrating and differentiating neurons (Doublecortin, NeuroD). Our data show a complete lack of hippocampal neurogenesis in nine of the species (Glossophaga soricina, Carollia perspicillata, Phyllostomus discolor, Nycteris macrotis, Nycteris thebaica, Hipposideros cyclops, Neoromicia rendalli, Pipistrellus guineensis, and Scotophilus leucogaster), while it was present at low levels in three species (Chaerephon pumila, Mops condylurus and Hipposideros caffer). Although not all antigens were recognized in all species, proliferation activity in the subventricular zone and rostral migratory stream was found in all species, confirming the appropriateness of our methods for detecting neurogenesis. The small variation of adult hippocampal neurogenesis within our sample of bats showed no indication of a correlation with phylogenetic relationship, foraging strategy, type of hunting habitat or diet. Our data indicate that the widely accepted notion of adult neurogenesis supporting spatial abilities needs to be considered carefully. Given their astonishing longevity, certain bat species may be useful subjects to compare adult neurogenesis with other long-living species, such as monkeys and humans, showing low rates of adult hippocampal neurogenesis.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
DOI：
10.1006/bbrc.1998.9698
发表时间：
1998-11-27
影响因子：
3.1
作者：
Matsuo, N;Kawamoto, S;Okubo, K
通讯作者：
Okubo, K
DOI：
10.1016/j.devbrainres.2004.03.021
发表时间：
2004-07-19
期刊：
DEVELOPMENTAL BRAIN RESEARCH
影响因子：
--
作者：
Bédard, A;Parent, A
通讯作者：
Parent, A
影响因子：
3.4
作者：
Lavenex, P;Steele, MA;Jacobs, LF
通讯作者：
Jacobs, LF
DOI：
10.1098/rspb.2004.2924
发表时间：
2005-01-22
影响因子：
4.7
作者：
Safi, K;Dechmann, DKN
通讯作者：
Dechmann, DKN