Effects of diethylstilbestrol exposure during gestation on both maternal and offspring behavior.
Effects of diethylstilbestrol exposure during gestation on both maternal and offspring behavior.
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DOI：
10.3389/fnins.2015.00079
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发表时间：
2015
影响因子：
4.3
通讯作者：
Matsumoto S
中科院分区：
文献类型：
--
作者：
Tomihara K;Zoshiki T;Kukita SY;Nakamura K;Isogawa A;Ishibashi S;Tanaka A;Kuraoka AS;Matsumoto S
妊娠期内分泌紊乱会损害后代的身体和行为发育。然而，目前尚不清楚内分泌紊乱是否也会损害母亲的行为，进而进一步导致后代的发育和行为障碍。从妊娠第11 ~ 17天开始，对C57BL/6J雌性小鼠口服合成非甾体雌激素己烯雌酚（DES），观察母鼠的母性行为。此外，我们还采用交叉培养的方法研究了子宫内DES暴露的直接影响和母体异常行为对后代的间接影响。在母亲中，怀孕期间内分泌紊乱会降低母性行为。此外，养母的内分泌干扰影响了幼鼠的焦虑相关行为和被动回避学习，而不管幼鼠在子宫内的暴露程度如何。在子宫内暴露于DES的影响，无论是否暴露于养母，也显示在女性后代中。这些结果证明了内分泌干扰物对母亲和后代的风险，并表明发育缺陷可能源于子宫毒性和异常的母亲护理。
Endocrine disruption during gestation impairs the physical and behavioral development of offspring. However, it is unclear whether endocrine disruption also impairs maternal behavior and in turn further contributes to the developmental and behavioral dysfunction of offspring. We orally administered the synthetic non-steroidal estrogen diethylstilbestrol (DES) to pregnant female C57BL/6J mice from gestation day 11–17 and then investigated the maternal behavior of mothers. In addition, we examined the direct effects of in utero DES exposure and the indirect effects of aberrant maternal behavior on offspring using the cross-fostering method. In mothers, endocrine disruption during gestation decreased maternal behavior. In addition, endocrine disruption of foster mother influenced anxiety-related behavior and passive avoidance learning of pups regardless of their exposure in utero. The influence of DES exposure in utero, irrespective of exposure to the foster mother, was also shown in female offspring. These results demonstrate the risks of endocrine disruptors on both mother as well as offspring and suggest that developmental deficits may stem from both in utero toxicity and aberrant maternal care.
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影响因子：
2.9
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