Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.
Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.
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类固醇激素调节大鼠子宫中一氧化氮和 cGMP 的产生。
DOI：
10.1210/endo.134.4.8137765
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发表时间：
1994
期刊：
影响因子：
4.8
通讯作者：
R. Garfield
中科院分区：
文献类型：
--
作者：
C. Yallampalli;M. Byam;S. Nelson;R. Garfield
Previously, we demonstrated the presence of an L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway in the rat uterus and that NO inhibits contractility during pregnancy but not during delivery. In the present study, we investigated the possible role of sex steroid hormones in the regulation of NO synthesis and cGMP generation. NO, measured as nitrite production, and cGMP were determined in full thickness uterine tissues from either pregnant rats on different gestational days or nonpregnant animals after treatment with steroid hormones. NO formation was low in tissues from nonpregnant rats, substantially increased during pregnancy and decreased during labor and immediately postpartum. The cGMP content in the same tissues followed a similar trend. Uterine nitrite production and cGMP levels from animals treated with estradiol and estradiol + progesterone were significantly lower compared to those treated with vehicle or progesterone. These data provide strong evidence that the NO-cGMP system is upregulated during pregnancy to maintain uterine quiescence and a rise in estrogen at term could inhibit this system and thus initiate labor.
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影响因子：
2.9
作者：
GREEN, LC;WAGNER, DA;TANNENBAUM, SR
通讯作者：
TANNENBAUM, SR
黄体酮和犬冠状动脉内皮依赖性反应的调节。
DOI：
10.1152/ajpregu.1991.261.4.r1022
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Miller,VM;Vanhoutte,PM
通讯作者：
Vanhoutte,PM
一氧化氮的自发释放抑制犬胃平滑肌的电瞬变、Ca2+ 瞬变和机械瞬变。
DOI：
10.1113/jphysiol.1992.sp018921
发表时间：
1992
期刊：
The Journal of physiology
影响因子：
--
作者：
Ozaki,H;Blondfield,DP;Hori,M;Publicover,NG;Kato,I;Sanders,KM
通讯作者：
Sanders,KM
妊娠子宫中的一氧化氮合酶活性在分娩时降低。
影响因子：
3.1
作者：
Natuzzi,ES;Ursell,PC;Harrison,M;Buscher,C;Riemer,RK
通讯作者：
Riemer,RK