Fabrication of mechanically robust bilayer membranes of hydroxyapatite/collagen composites
Fabrication of mechanically robust bilayer membranes of hydroxyapatite/collagen composites
复制标题
羟基磷灰石/胶原复合材料的机械坚固双层膜的制造
DOI：
10.1016/j.matlet.2021.129514
复制
发表时间：
2021
影响因子：
3
通讯作者：
Ikoma Toshiyuki
中科院分区：
文献类型：
--
作者：
Irawan Vincent;Kajiwara Daichi;Nakagawa Yasuhiro;Ikoma Toshiyuki
羟基磷灰石（HAp）和胶原蛋白（Col）复合材料已被研究作为双层膜用于引导骨再生的应用。本研究基于顺序或同时 Col 自组装和乙醇交换方法，研究了不同重量比的 HAp/Col 双层膜的制备。该膜表现出 HAp 嵌入 Col 原纤维中。顺序自组装的膜显示出不同的 HAp/Col 层，这些层通过由细长的胶原原纤维组成的界面互连。相比之下，同时自组装的膜具有连续的界面。双层膜的拉伸强度在 8-50MPa 范围内，具体取决于 HAp/Col 比率。顺序自组装和乙醇交换方法的结合成功地制备了具有独特的逐层结构和稳健的机械性能的 HAp/Col 双层膜。
Hydroxyapatite (HAp) and collagen (Col) composites have been investigated as bilayer membranes for the application of guided bone regeneration. This study investigated the fabrication of HAp/Col bilayer membranes with different weight ratios based on the sequential or simultaneous Col self-assembly, and ethanol-exchanged methods. The membranes exhibited HAp embedded in Col fibrils. The sequentially self-assembled membranes showed distinct HAp/Col layers interconnected by interfaces consisting of elongated collagen fibrils. In contrast, the simultaneously self-assembled membrane had a continuous interface. The bilayer membranes had a tensile strength in the range of 8–50 MPa, depending on the HAp/Col ratio. The combination of sequential self-assembly and ethanol-exchanged methods is successful in fabricating HAp/Col bilayer membranes with distinct layer-by-layer structures and robust mechanical properties.
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DOI：
10.1016/j.msec.2019.109959
发表时间：
2019-11
期刊：
Materials science & engineering. C, Materials for biological applications
影响因子：
--
作者：
Jing Wang;Y. Qu;Chaoqun Chen;Jian Sun;H. Pan;C. Shao;R. Tang;Xinhua Gu
通讯作者：
Jing Wang;Y. Qu;Chaoqun Chen;Jian Sun;H. Pan;C. Shao;R. Tang;Xinhua Gu
影响因子：
3.3
作者：
Ikoma, T;Yamazaki, A;Akao, M
通讯作者：
Akao, M
胶原和羟基磷灰石复合膜作为生物医学应用的载药支持
DOI：
--
发表时间：
2017
期刊：
影响因子：
--
作者：
Daichi Kajiwara;T. Ikoma
通讯作者：
T. Ikoma
影响因子：
7
作者：
Irawan, Vincent;Sasaki, Yusuke;Ikoma, Toshiyuki
通讯作者：
Ikoma, Toshiyuki