Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond.
Antimicrobial strategies centered around reactive oxygen species--bactericidal antibiotics, photodynamic therapy, and beyond.
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DOI：
10.1111/1574-6976.12026
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发表时间：
2013-11
影响因子：
11.3
通讯作者：
Hamblin MR
中科院分区：
文献类型：
--
作者：
Vatansever F;de Melo WC;Avci P;Vecchio D;Sadasivam M;Gupta A;Chandran R;Karimi M;Parizotto NA;Yin R;Tegos GP;Hamblin MR
活性氧（ROS）可以攻击多种靶标以发挥抗微生物活性，这解释了它们在介导宿主防御多种病原体方面的多功能性。大多数ROS是由分子氧的部分还原形成的。四种主要的活性氧被认为是：超氧化物（O2·−），过氧化氢（H2O2），羟基自由基（·OH）和单线态氧（1O2），但它们表现出非常不同的动力学和活性水平。O2·−和H2O2的影响不如·OH和1O2那么严重，因为前者的反应性要小得多，并且可以被氧化应激诱导的内源性抗氧化剂（酶和非酶）解毒。相比之下，没有酶可以解毒·OH或1O2，使它们具有极强的毒性和急性致死性。本文综述了活性氧形成的各种方法及其作用机制。抗氧化剂防御微生物细胞中的活性氧和使用活性氧的抗微生物宿主防御系统。主要利用ROS的抗微生物方法包括杀菌抗生素和非药物方法，如光动力疗法、二氧化钛凝胶、冷等离子体和药用蜂蜜。一个简短的最后一节涵盖，活性氮物种，和相关的治疗，如酸化亚硝酸盐和一氧化氮释放纳米粒子。
Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial activity, which accounts for their versatility in mediating host defense against a broad range of pathogens. Most ROS are formed by the partial reduction of molecular oxygen. Four major ROS are recognized comprising: superoxide (O2•−), hydrogen peroxide (H2O2), hydroxyl radical (•OH), and singlet oxygen (1O2), but they display very different kinetics and levels of activity. The effects of O2•− and H2O2 are less acute than those of •OH and 1O2, since the former are much less reactive and can be detoxified by endogenous antioxidants (both enzymatic and non-enzymatic) that are induced by oxidative stress. In contrast, no enzyme can detoxify •OH or 1O2, making them extremely toxic and acutely lethal. The present review will highlight the various methods of ROS formation and their mechanism of action. Antioxidant defenses against ROS in microbial cells and the use of ROS by antimicrobial host defense systems are covered. Antimicrobial approaches primarily utilizing ROS comprise both bactericidal antibiotics, and non-pharmacological methods such as photodynamic therapy, titanium dioxide photocatalysis, cold plasma and medicinal honey. A brief final section covers, reactive nitrogen species, and related therapeutics, such as acidified nitrite and nitric oxide releasing nanoparticles.
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DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
11.3
作者：
Beisel CL;Storz G
通讯作者：
Storz G
影响因子：
3.7
作者：
Alkawareek MY;Algwari QT;Laverty G;Gorman SP;Graham WG;O'Connell D;Gilmore BF
通讯作者：
Gilmore BF
影响因子：
4.6
作者：
Alzahrani, Hasan A.;Alsabehi, Rashid;Bakhotmah, Balkees A.
通讯作者：
Bakhotmah, Balkees A.
影响因子：
3.3
作者：
BERTOLONI, G;SALVATO, B;JORI, G
通讯作者：
JORI, G