Stability properties of neuronal microtubules.
Stability properties of neuronal microtubules.
复制标题
DOI：
10.1002/cm.21286
复制
发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Leo L
中科院分区：
文献类型：
--
作者：
Baas PW;Rao AN;Matamoros AJ;Leo L
神经元是终末分化细胞，其微管阵列不是用于细胞分裂，而是作为细长轴突和树突所需的结构元件。除了充当提供神经元形状的承压支柱之外，微管还充当细胞器运输的定向铁路。神经元微管的稳定性特性在生物医学文献中经常被讨论为对神经系统的发育和维持至关重要，并且最近作为神经退行性疾病病因学的核心而受到关注。目前正在研究影响微管稳定性的药物作为神经系统疾病和损伤的潜在疗法。然而，文献中如何讨论微管稳定性问题往往缺乏一致性，这可能会影响实验的设计和解释以及潜在的治疗方案。神经元微管被认为比分裂细胞中的微管更稳定。平均而言，这是事实，但神经元中除了丰富的稳定微管部分外，还存在丰富的不稳定微管部分。两者在功能上都很重要。各个微管由稳定性特性不同的结构域组成，这些结构域的组成以及与神经元中各种微管相关蛋白相互作用的方式也可能显着不同。人们已经讨论了无数蛋白质和途径作为神经元微管稳定性的潜在贡献者。
Neurons are terminally differentiated cells that use their microtubule arrays not for cell division but rather as architectural elements required for the elaboration of elongated axons and dendrites. In addition to acting as compression-bearing struts that provide for the shape of the neuron, microtubules also act as directional railways for organelle transport. The stability properties of neuronal microtubules are commonly discussed in the biomedical literature as crucial to the development and maintenance of the nervous system, and have recently gained attention as central to the etiology of neurodegenerative diseases. Drugs that affect microtubule stability are currently under investigation as potential therapies for disease and injury of the nervous system. There is often a lack of consistency, however, in how the issue of microtubule stability is discussed in the literature, and this can affect the design and interpretation of experiments as well as potential therapeutic regimens. Neuronal microtubules are considered to be more stable than microtubules in dividing cells. On average, this is true, but in addition to an abundant stable microtubule fraction in neurons, there is also an abundant labile microtubule fraction. Both are functionally important. Individual microtubules consist of domains that differ in their stability properties, and these domains can also differ markedly in their composition as well as how they interact with various microtubule-related proteins in the neuron. Myriad proteins and pathways have been discussed as potential contributors to microtubule stability in neurons.
登录
查看更多内容
DOI：
10.1002/neu.10281
发表时间：
2004-01-01
期刊：
JOURNAL OF NEUROBIOLOGY
影响因子：
--
作者：
Baas, PW;Buster, DW
通讯作者：
Buster, DW
影响因子：
7.8
作者：
BAAS, PW;HEIDEMANN, SR
通讯作者：
HEIDEMANN, SR
影响因子：
7.8
作者：
Baas, P W;Black, M M
通讯作者：
Black, M M
DOI：
10.1083/jcb.109.6.3085
发表时间：
1989-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baas PW;Black MM;Banker GA
通讯作者：
Banker GA
影响因子：
3
作者：
Baas PW;Lin S
通讯作者：
Lin S