Hooks and comets: The story of microtubule polarity orientation in the neuron.

Hooks and comets: The story of microtubule polarity orientation in the neuron.
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DOI:
10.1002/dneu.20818
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发表时间:
2011-06
影响因子:
3
通讯作者:
Lin S
Lin S
中科院分区:
医学3区
文献类型:
--
作者:
Baas PW;Lin S

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人们普遍认为,轴突和树突内微管极性方向的特征模式是区分这些神经元突起的成分和形态差异的基础。脊椎动物神经元轴突呈均匀的正端-远端微管,而树突呈非均匀定向的微管。苍蝇轴突也显示均匀的正端-远端微管,但其树突微管几乎一致的负端-远端。本文讨论了这些发现的历史,它们对整个动物界神经元极性调节的影响,以及神经元建立定义轴突和树突的不同微管极性模式的潜在机制。
It is widely believed that signature patterns of microtubule polarity orientation within axons and dendrites underlie compositional and morphological differences that distinguish these neuronal processes from one another. Axons of vertebrate neurons display uniformly plus-end-distal microtubules, whereas their dendrites display non-uniformly oriented microtubules. Fly axons also display uniformly plus-end-distal microtubules, but their dendritic microtubules are nearly uniformly minus-end-distal. Discussed in this article are the history of these findings, their implications for the regulation of neuronal polarity across the animal kingdom, and potential mechanisms by which neurons establish the distinct microtubule polarity patterns that define axons and dendrites.
DOI: 10.1083/jcb.118.6.1333
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