Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging.

Magnetic resonance multitasking for motion-resolved quantitative cardiovascular imaging.
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DOI:
10.1038/s41551-018-0217-y
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发表时间:
2018-04
影响因子:
28.1
通讯作者:
Li D
Li D
中科院分区:
工程技术1区
文献类型:
--
作者:
Christodoulou AG;Shaw JL;Nguyen C;Yang Q;Xie Y;Wang N;Li D

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定量心血管磁共振(CMR)成像可用于表征纤维化、水肿、缺血、炎症和其他疾病状况。然而,需要通过心电图(ECG)控制、呼吸控制和对比度加权选择的组合来减少由身体运动引起的伪影,这使得CMR检查变得冗长。在这里,我们表明,生理运动和其他动态过程可以被概念化为多个时间维度,可以通过低秩张量成像解决,允许运动分辨定量成像与多达四个时间维度。这种连续采集方法(我们将其命名为心血管MR多任务处理)可捕获(而不是避免)运动、放松和其他动态,从而在不使用ECG触发或屏气的情况下有效执行定量CMR。我们证明,CMR多任务允许T1映射,T1-T2映射和时间分辨T1映射的心肌灌注没有ECG信息和/或在自由呼吸条件下。CMR多任务处理可能为开发用于心血管健康定量评估的免设置CMR成像提供基础。
Quantitative cardiovascular magnetic resonance (CMR) imaging can be used to characterize fibrosis, oedema, ischaemia, inflammation and other disease conditions. However, the need to reduce artefacts arising from body motion through a combination of electrocardiography (ECG) control, respiration control, and contrast-weighting selection makes CMR exams lengthy. Here, we show that physiological motions and other dynamic processes can be conceptualized as multiple time dimensions that can be resolved via low-rank tensor imaging, allowing for motion-resolved quantitative imaging with up to four time dimensions. This continuous-acquisition approach, which we name cardiovascular MR multitasking, captures — rather than avoids — motion, relaxation and other dynamics to efficiently perform quantitative CMR without the use of ECG triggering or breath holds. We demonstrate that CMR multitasking allows for T1 mapping, T1-T2 mapping and time-resolved T1 mapping of myocardial perfusion without ECG information and/or in free-breathing conditions. CMR multitasking may provide a foundation for the development of setup-free CMR imaging for the quantitative evaluation of cardiovascular health.
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