Ventricular enlargement and progressive reduction of cortical gray matter are linked in prodromal youth who develop psychosis.
Ventricular enlargement and progressive reduction of cortical gray matter are linked in prodromal youth who develop psychosis.
复制标题
心脏病的前驱青年有联系的心室增大和逐步减少皮质灰质。
DOI：
10.1016/j.schres.2017.02.014
复制
发表时间：
2017-11
影响因子：
4.5
通讯作者：
North American Prodrome Longitudinal Study (NAPLS) Consortium
中科院分区：
文献类型：
--
作者：
Chung Y;Haut KM;He G;van Erp TGM;McEwen S;Addington J;Bearden CE;Cadenhead K;Cornblatt B;Mathalon DH;McGlashan T;Perkins D;Seidman LJ;Tsuang M;Walker E;Woods SW;Cannon TD;North American Prodrome Longitudinal Study (NAPLS) Consortium
在最近的一项前瞻性纵向神经成像研究中，临床高危(CHR)患者后来发展为完全精神病，在应用严格的校正进行多次比较后，显示出前额叶皮质(PFC)上、内侧灰质变薄的加速速度和脑室系统的扩张。虽然皮质和皮质下体积减少和脑室扩大是精神分裂症患者结构性脑异常的良好特征，但先前没有研究评估这些神经解剖学指标的进行性变化是否在精神病发病前的时间上存在联系。因此，我们使用北美前驱纵向研究的全脑水平的纵向神经成像数据来研究皮质灰质厚度的变化与脑室容量之间的关系。结果表明，脑室扩张在时间上与灰质进行性减少有关，而不是与近侧皮质下区域的结构变化有关，在CHR青年中广泛分布的皮质区域包括上、内、外、下PFC、颞上回和顶叶皮质。相比之下，健康对照组没有表现出同样的关联模式。通过对研究参与者的子集进行第三次核磁共振扫描评估，进一步复制了主要发现，这些参与者又被跟踪了一年。这些发现表明，与精神病风险相关的灰质区域异常变薄的速度不仅限于在我们的初步研究中幸存下来的PFC区域，而且还延伸到以前与精神分裂症有关的其他皮质区域。
In a recent prospective longitudinal neuroimaging study, clinical high-risk (CHR) individuals who later developed full-blown psychosis showed an accelerated rate of gray matter thinning in superior and medial prefrontal cortex (PFC) and expansion of the ventricular system after applying a stringent correction for multiple comparisons. Although cortical and subcortical volume loss and enlarged ventricles are well characterized structural brain abnormalities among patients with schizophrenia, no prior study has evaluated whether these progressive changes of neuroanatomical indicators are linked in time prior to onset of psychosis. Therefore, we investigated the relationship between the changes in cortical gray matter thickness and ventricular volume using the longitudinal neuroimaging data from the North American Prodrome Longitudinal Study at the whole-brain level. The results showed that ventricular expansion is linked in time to progressive reduction of gray matter, rather than to structural changes in proximal subcortical regions, in a broadly distributed set of cortical regions among CHR youth, including superior, medial, lateral, and inferior PFC, superior temporal gyrus, and parietal cortices. In contrast, healthy controls did not show the same pattern of associations. The main findings were further replicated using a third assessment wave of MRI scans in a subset of study participants who were followed for an additional year. These findings suggest that the gray matter regions exhibiting aberrant rates of thinning in relation to psychosis risk are not limited to the PFC regions that survived the statistical threshold in our primary study, but also extend to other cortical regions previously implicated in schizophrenia.
登录
查看更多内容
DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
5.7
作者：
Reuter, Martin;Schmansky, Nicholas J.;Rosas, H. Diana;Fischl, Bruce
通讯作者：
Fischl, Bruce
影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
17.7
作者：
Gaser, C;Nenadic, I;Buchsbaum, MS
通讯作者：
Buchsbaum, MS