Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center retrospective study.
Etiologies and clinical characteristics of young patients with angle-closure glaucoma: a 15-year single-center retrospective study.
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年轻闭角型青光眼患者的病因和临床特征：15年单中心回顾性研究
DOI：
10.1007/s00417-021-05172-6
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Sun X
中科院分区：
文献类型：
--
作者：
Gao F;Wang J;Chen J;Wang X;Chen Y;Sun X
探讨中国40岁以下闭角型青光眼（ACG）患者的病因和临床特征。本回顾性非比较病例系列纳入2002年至2017年复旦大学眼耳鼻喉科医院收治的ACG诊断且诊断年龄小于或等于40岁的住院患者。通过综合查阅病历，分析所有患者的根本原因和临床特征。符合标准的患者共有298例（463只眼），其中女性153例（51.3%），男性145例（48.7%）；平均年龄为 25.6±13.0 岁。原发性闭角型青光眼（PACG）、葡萄膜炎和眼前节发育不全（ASD）是本组患者中排名前三位的病因，分别占患者总数的32.6%、20.3%和15.1%。 PACG 主要发生在 30 岁以后，ASD 是 20 岁以下患者发生 ACG 的首要原因。其他已知的病因包括虹膜角膜内皮综合征、新生血管性青光眼、纳米眼球、色素性视网膜炎、球形晶状体、卵状囊肿、持续性胎儿脉管系统、虹膜睫状体囊肿、先天性视网膜劈裂、马凡氏综合征、早产儿视网膜病、家族性渗出性视网膜病变 玻璃体视网膜病变、先天性视网膜皱襞、Coat 病和神经纤维瘤病。我们描述了中国年轻患者中 ACG 的罕见表现。虽然不寻常，但大多数病因是可以确定的。因此，对于年轻的ACG患者，需要进行更仔细、更全面的检查，做到早期发现、及时治疗。在线版本包含可在 10.1007/s00417-021-05172-6 获取的补充材料。
To investigate the etiologies and the clinical characteristics of angle-closure glaucoma (ACG) patients younger than 40 years old in Chinese. Inpatients with diagnosis of ACG and diagnosed age younger than or equal to 40 years old, who were admitted in Eye, Ear, Nose, and Throat Hospital Fudan University from 2002 to 2017, were included in this retrospective non-comparative case series. The underlying causes and clinical features for all the patients were analyzed by comprehensive review of medical charts. A total of 298 patients (463 eyes) met the criteria, including 153 females (51.3%) and 145 males (48.7%); the mean age was 25.6 ± 13.0 years. Primary angle-closure glaucoma (PACG), uveitis, and anterior segment dysgenesis (ASD) were the top three etiologies in our patients, which accounted for 32.6%, 20.3%, and 15.1% of the total patients respectively. PACG mainly occurs after 30 years of age and ASD is the top reason of ACG in patients younger than 20 years old. Other known etiologies include iridocorneal endothelial syndrome, neovascular glaucoma, nanophthalmos, retinitis pigmentosa, spherophakia, bestrophinopathy, persistent fetal vasculature, iridociliary cysts, congenital retinoschisis, Marfan’s syndrome, retinopathy of prematurity, familial exudative vitreoretinopathy, congenital retinal folds, Coat’s disease, and neurofibromatosis. We described the uncommon presentation of ACG in Chinese young patients. Although unusual, most of the etiologies could be identified. Therefore, more careful and comprehensive examinations are needed for early detection and timely treatment for young ACG patients. The online version contains supplementary material available at 10.1007/s00417-021-05172-6.
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影响因子：
--
作者：
Hollander, DA;Barricks, ME;Irvine, AR
通讯作者：
Irvine, AR
影响因子：
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作者：
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DOI：
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发表时间：
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