Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation.
Microchimerism in salivary glands after blood- and marrow-derived stem cell transplantation.
复制标题
DOI：
10.1016/j.bbmt.2010.09.021
复制
发表时间：
2011-03
影响因子：
4.3
通讯作者：
Mezey, Eva
中科院分区：
文献类型：
--
作者：
Tran, Simon D.;Redman, Robert S.;Barrett, A. John;Pavletic, Steven Z.;Key, Sharon;Liu, Younan;Carpenter, Ashley;Nguyen, Hieu M.;Sumita, Yoshinori;Baum, Bruce J.;Pillemer, Stanley R.;Mezey, Eva
血液和骨髓来源的干细胞（BMDSC）为心血管和自身免疫性疾病提供疾病改善作用。在几种受体组织中已经报道了来自供体BMDSC的微嵌合体。我们假设这一发现表明BMDSC在治疗唾液腺功能障碍中的潜在用途。我们调查了5例接受男性供体骨髓或血液干细胞移植的女性唾液腺活检中Y染色体阳性细胞的存在。移植后1 ~ 16年，所有受者均在其唾液腺的腺泡、导管和间质中表现出散在的Y染色体阳性细胞（平均1.01%）。潜在地，这些细胞可以是移植耐受性的标志物，有助于肿瘤上皮组织，或移植到损伤部位。此外，BMDSC的移植可用于治疗干燥综合征和头颈部癌症治疗性放射损伤的唾液腺。
Blood- and marrow-derived stem cells (BMDSCs) provide disease-ameliorating effects for cardiovascular and autoimmune diseases. Microchimerism from donor BMDSCs has been reported in several recipient tissues. We hypothesized that this finding suggests a potential use of BMDSCs in the treatment of salivary dysfunctions. We investigated the presence of Y chromosome-positive cells in salivary gland biopsies of 5 females who had received a marrow or blood stem cell transplant from male donors. One to 16 years after transplantation, all recipients exhibited scattered Y chromosome-positive cells in the acini, ducts, and stroma of their salivary glands (mean of 1.01%). Potentially, these cells can be markers of transplantation tolerance, contribute to neoplastic epithelial tissues, or engraft at sites of injury. In addition, transplantation of BMDSCs could be used for treatment of Sjögren’s syndrome and salivary glands damaged by therapeutic irradiation for cancers of the head and neck.
登录
查看更多内容
影响因子：
29.4
作者：
Matsumoto, T;Okamoto, R;Watanabe, M
通讯作者：
Watanabe, M
影响因子：
9.8
作者：
Ikoma, Tomomi;Kyo, Satoru;Inoue, Masaki
通讯作者：
Inoue, Masaki
影响因子：
3.2
作者：
Toth, Zsuzsanna E.;Mezey, Eva
通讯作者：
Mezey, Eva
影响因子：
4.8
作者：
Ishikawa, F;Yasukawa, M;Harada, M
通讯作者：
Harada, M
影响因子：
158.5
作者：
Korbling, M;Katz, RL;Estrov, Z
通讯作者：
Estrov, Z