Axonemal positioning and orientation in three-dimensional space for primary cilia: what is known, what is assumed, and what needs clarification.
Axonemal positioning and orientation in three-dimensional space for primary cilia: what is known, what is assumed, and what needs clarification.
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DOI：
10.1002/dvdy.22756
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发表时间：
2011-11
影响因子：
2.5
通讯作者：
Wilsman, Norman J.
中科院分区：
文献类型：
--
作者：
Farnum, Cornelia E.;Wilsman, Norman J.
纤毛轴丝的两个位置特征--当它从细胞中出现时在质膜上的位置，以及它在三维空间中的方向--已知对于主动运动纤毛（包括结纤毛）的最佳功能以及与特殊感觉相关的修饰纤毛是至关重要的。然而，这些位置特征尚未被分析到任何显着程度的初级纤毛。这篇综述简要总结了这两个位置的特点，在广泛的纤毛知识的历史，强调其重要性，正确的功能。然后，审查重点是什么是已知的这些相同的位置特性，初级纤毛在所有主要的组织类型，他们已经报告。审查强调主要领域，将是富有成效的未来研究了解如何定位和3-D方向的初级纤毛可能与他们假设的信号作用在不同的细胞群体。
Two positional characteristics of the ciliary axoneme – its location on the plasma membrane as it emerges from the cell, and its orientation in three-dimensional space – are known to be critical for optimal function of actively motile cilia (including nodal cilia), as well as for modified cilia associated with special senses. However, these positional characteristics have not been analyzed to any significant extent for primary cilia. This review briefly summarizes the history of knowledge of these two positional characteristics across a wide spectrum of cilia, emphasizing their importance for proper function. Then the review focuses what is known about these same positional characteristics for primary cilia in all major tissue types where they have been reported. The review emphasizes major areas that would be productive for future research for understanding how positioning and 3-D orientation of primary cilia may be related to their hypothesized signaling roles within different cellular populations.
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DOI：
10.1016/s0022-5320(61)80019-1
发表时间：
1961-01-01
期刊：
JOURNAL OF ULTRASTRUCTURE RESEARCH
影响因子：
--
作者：
BARNES, BG
通讯作者：
BARNES, BG
影响因子：
13.6
作者：
Benzing, Thomas;Simons, Matias;Walz, Gerd
通讯作者：
Walz, Gerd
DOI：
10.1016/j.cub.2009.07.034
发表时间：
2009-09-15
期刊：
Current biology : CB
影响因子：
--
作者：
Anderson CT;Stearns T
通讯作者：
Stearns T
影响因子：
3
作者：
Ascenzi, Maria-Grazia;Lenox, Michelle;Farnum, Cornelia
通讯作者：
Farnum, Cornelia
影响因子：
2
作者：
Ascenzi, Maria-Grazia;Blanco, Christian;Drayer, Ian;Kim, Hannah;Wilson, Ryan;Retting, Kelsey N.;Lyons, Karen M.;Mohler, George
通讯作者：
Mohler, George