B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis.
B-Cells and Antibodies as Contributors to Effector Immune Responses in Tuberculosis.
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DOI：
10.3389/fimmu.2021.640168
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发表时间：
2021
影响因子：
7.3
通讯作者：
Joosten SA
中科院分区：
文献类型：
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作者：
Rijnink WF;Ottenhoff THM;Joosten SA
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is still a major threat to mankind, urgently requiring improved vaccination and therapeutic strategies to reduce TB-disease burden. Most present vaccination strategies mainly aim to induce cell-mediated immunity (CMI), yet a series of independent studies has shown that B-cells and antibodies (Abs) may contribute significantly to reduce the mycobacterial burden. Although early studies using B-cell knock out animals did not support a major role for B-cells, more recent studies have provided new evidence that B-cells and Abs can contribute significantly to host defense against Mtb. B-cells and Abs exist in many different functional subsets, each equipped with unique functional properties. In this review, we will summarize current evidence on the contribution of B-cells and Abs to immunity toward Mtb, their potential utility as biomarkers, and their functional contribution to Mtb control.
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DOI：
10.4049/jimmunol.1003189
发表时间：
2011-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Balu S;Reljic R;Lewis MJ;Pleass RJ;McIntosh R;van Kooten C;van Egmond M;Challacombe S;Woof JM;Ivanyi J
通讯作者：
Ivanyi J
DOI：
10.4049/jimmunol.1601775
发表时间：
2017-07-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Boyaka PN
通讯作者：
Boyaka PN
影响因子：
30.5
作者：
Bermejo, Daniela A.;Jackson, Shaun W.;Gorosito-Serran, Melisa;Acosta-Rodriguez, Eva V.;Amezcua-Vesely, Maria C.;Sather, Blythe D.;Singh, Akhilesh K.;Khim, Socheath;Mucci, Juan;Liggitt, Denny;Campetella, Oscar;Oukka, Mohamed;Gruppi, Adriana;Rawlings, David J.
通讯作者：
Rawlings, David J.
针对结核分枝杆菌RV2031的IgA和IgG区分肺结核患者，结核分枝杆菌感染和未感染的个体。
影响因子：
3.7
作者：
Abebe F;Belay M;Legesse M;K L M C F;Ottenhoff THM
通讯作者：
Ottenhoff THM
影响因子：
30.3
作者：
Achkar JM;Casadevall A
通讯作者：
Casadevall A