Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.
Prevalence and risk factors for hyperhomocysteinemia: a population-based cross-sectional study from Hunan, China.
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高同型半胱氨酸血症的患病率和危险因素：中国湖南省的一项基于人群的横断面研究。
DOI：
10.1136/bmjopen-2020-048575
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发表时间：
2021-12-06
期刊：
影响因子：
2.9
通讯作者：
Hocher B
中科院分区：
文献类型：
--
作者：
Yang Y;Zeng Y;Yuan S;Xie M;Dong Y;Li J;He Q;Ye X;Lv Y;Hocher CF;Kraemer BK;Hong X;Hocher B
目的 高同型半胱氨酸血症是心血管疾病的独立危险因素。我们的目的是调查高同型半胱氨酸血症的患病率和危险因素，特别是可改变的生活方式因素，例如吸烟行为和饮食因素。设计基于人群的横断面研究。设置中国湖南省参与者 2013 年 7 月至 2014 年 3 月期间，共有 4012 名参与者完成了这项研究。中位年龄为 55 岁（四分位距：45-63）岁，其中男性 1644 名（41%），女性 2368 名（59%）。主要结果指标同型半胱氨酸水平通过微孔板酶联免疫分析法测定。高同型半胱氨酸血症定义为≥15μmol/L。采用问卷调查调查高同型半胱氨酸血症的潜在危险因素。使用单变量或多变量逻辑回归模型确定粗比值比 (OR) 或调整后的 OR（95%CI）。结果 高同型半胱氨酸血症的患病率为 35.4%（男性为 45.4%，女性为 28.5%）。年龄增加一岁与高同型半胱氨酸血症风险增加 2% 显着相关（OR=1.02，95%CI：1.01 至 1.03）。 BMI每增加一个单位，高同型半胱氨酸血症的风险就会增加5%（OR=1.05，95%CI：1.03至1.07）。与不吸烟者相比，吸烟者患高同型半胱氨酸血症的风险高出24%（OR=1.24，95%CI：1.006至1.53），而戒烟者患高同型半胱氨酸血症的风险没有显着差异（OR=1.14，95%CI：0.85至1.54）。与每天至少食用一次水果和蔬菜的人相比，每天食用少于一次的人患高同型半胱氨酸血症的风险显着较高（OR=1.29，95%CI：1.11至1.50）。此外，我们发现，教育水平或饮酒与高同型半胱氨酸血症的风险存在显着的性别交互作用（p交互作用<0.05）。结论 BMI较高和年龄较大是高同型半胱氨酸血症的潜在危险因素。当前吸烟但未戒烟与高同型半胱氨酸血症风险较高相关。食用水果和蔬菜可能对高同型半胱氨酸血症有保护作用。饮酒量或教育水平可能会相互作用，影响高同型半胱氨酸血症的风险。
Objectives Hyperhomocysteinemia is an independent risk factor for cardiovascular diseases. We aimed to investigate the prevalence and risk factors for hyperhomocysteinemia, especially modifiable lifestyle factors, such as smoking behaviour and dietary factors. Design Population-based cross-sectional study. Setting Hunan Province, China Participants A total of 4012 participants completed the study, between July 2013 and March 2014. The median age is 55 (interquartile range: 45–63) years, with 1644 males (41%) and 2368 females (59%). Main outcome measures Homocysteine level were measured by the microplate enzyme immunoassay method. Hyperthomocysteinemia was defined as ≥15 µmol/L. Questionnaire was used to investigate potential risk factors of hyperhomocysteinemia. Crude odd ratio (OR) or adjusted OR with 95% CI were determined by using univariable or multivariable logistic regression models. Results The prevalence of hyperhomocysteinemia is 35.4% (45.4% vs 28.5% for men, women, respectively). One-year increase in age is significantly associated with 2% higher risk of hyperhomocysteinemia (OR=1.02, 95% CI: 1.01 to 1.03). One unit increase of BMI is associated with 5% higher risk of hyperhomocysteinemia (OR=1.05, 95% CI: 1.03 to 1.07). Compared with the non-smoker, smoking participants have a 24% higher risk of hyperhomocysteinemia (OR=1.24, 95% CI: 1.006 to 1.53), while the risk for those quitting smoking are not significantly different (OR=1.14, 95% CI: 0.85 to 1.54). compared with those consuming fruit and vegetable at least once every day, those consuming less than once every day had a significantly higher risk of hyperhomocysteinemia (OR=1.29, 95% CI:1.11 to 1.50). In addition, we found there were significant sex interaction with education level or alcohol drinking on the risk of hyperhomocysteinemia (pinteraction <0.05). Conclusions Higher BMI and older age are potential risk factors for hyperhomocysteinemia. Current smoking but not quitting smoking is associated with higher risk of hyperhomocysteinemia. Fruit and vegetable consumption may have protective effect against hyperhomocysteinemia. Alcohol consumption or education level might interact to influence the risk of hyperhomocysteinemia.
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