Distinct Components of Photoperiodic Light Are Differentially Encoded by the Mammalian Circadian Clock.
Distinct Components of Photoperiodic Light Are Differentially Encoded by the Mammalian Circadian Clock.
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DOI：
10.1177/0748730420929217
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发表时间：
2020-08
影响因子：
3.5
通讯作者：
McMahon DG
中科院分区：
文献类型：
--
作者：
Tackenberg MC;Hughey JJ;McMahon DG
季节性光周期影响多种生理功能，并通过昼夜节律系统的光周期编码介导。尽管我们知道季节性光输入和下游昼夜节律变化之间的密切联系，但对编码并诱导昼夜节律系统持续变化的季节性光周期的特定组成部分知之甚少。使用三个T循环（23、24、26小时）的组合。和每个T周期两个光周期（长和短，占空比缩放到每个T周期），我们研究了夹带对这六个光周期的后效应。我们在体内测量运动行为持续时间（α）、周期（τ）和夹带相位角（θ），并在体外测量SCN相位分布（σ θ）、τ和θ，以完善我们对影响特定昼夜节律特性的关键光成分的理解。我们发现，光周期和T周期长度都驱动确定在体内的α，但不同的影响后效应的α和τ，与光周期驱动的α和光周期长度和T周期长度的变化相结合，影响τ。使用骨架光周期，我们证明，在体内光周期是由参数和非参数组件，而在α的变化是驱动非参数。在离体SCN中，我们发现PER2荧光素酶节律的τ和σ与其可能的行为对应物（运动活动节律的τ和α）密切相关，同时也证实了先前报告的基因表达节律的τ后效与T周期反应的行为τ后效呈负相关。我们证明，SCN内的σ σ变化，被认为是体内α变化的基础，主要是非参数诱导的。综上所述，我们的研究结果表明，季节性光输入的不同组成部分对α，α和τ的影响不同，并表明可能存在单独的机制来驱动季节性光介导的昼夜节律行为的持续变化。
Seasonal light cycles influence multiple physiological functions and are mediated through photoperiodic encoding by the circadian system. Despite our knowledge of the strong connection between seasonal light input and downstream circadian changes, less is known about the specific components of seasonal light cycles that are encoded and induce persistent changes in the circadian system. Using combinations of three T cycles (23, 24, 26 hr.) and two photoperiods per T cycle (Long and Short, with duty cycles scaled to each T cycle), we investigate after-effects of entrainment to these six light cycles. We measure locomotor behavior duration (α), period (τ), and entrained phase angle (ψ) in vivo, and SCN phase distribution (σϕ), τ, and ψ ex vivo in order to refine our understanding of critical light components for influencing particular circadian properties. We find that photoperiod and T cycle length both drive determination of in vivo ψ but differentially influence after-effects in α and τ, with photoperiod driving changes in α and photoperiod length and T cycle length combining to influence τ. Using skeleton photoperiods, we demonstrate that in vivo ψ is determined by both parametric and non-parametric components, while changes in α are driven non-parametrically. Within the ex vivo SCN, we find that ψ and σϕ of the PER2∷LUCIFERASE rhythm follow closely with their likely behavioral counterparts (ψ and α of the locomotor activity rhythm), while also confirming previous reports of τ after-effects of gene expression rhythms showing negative correlations with behavioral τ after-effects in response to T cycles. We demonstrate that within-SCN σϕ changes, thought to underly α changes in vivo, are induced primarily non-parametrically. Taken together, our results demonstrate distinct components of seasonal light input differentially influence ψ, α, and τ, and suggest the possibility of separate mechanisms driving the persistent changes in circadian behaviors mediated by seasonal light.
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影响因子：
3.5
作者：
Beersma, Domien G. M.;Gargar, Kim A.;Daan, Serge
通讯作者：
Daan, Serge
DOI：
10.1523/jneurosci.3801-08.2009
发表时间：
2009-02-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ciarleglio CM;Gamble KL;Axley JC;Strauss BR;Cohen JY;Colwell CS;McMahon DG
通讯作者：
McMahon DG
DOI：
10.1073/pnas.1319820111
发表时间：
2014-07-01
影响因子：
11.1
作者：
Farajnia, Sahar;van Westering, Tirsa L. E.;Michel, Stephan
通讯作者：
Michel, Stephan
影响因子：
16.2
作者：
Evans JA;Leise TL;Castanon-Cervantes O;Davidson AJ
通讯作者：
Davidson AJ
影响因子：
3.7
作者：
Buijink MR;Almog A;Wit CB;Roethler O;Olde Engberink AH;Meijer JH;Garlaschelli D;Rohling JH;Michel S
通讯作者：
Michel S