Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion.
Lycopene: A Critical Review of Digestion, Absorption, Metabolism, and Excretion.
复制标题
DOI：
10.3390/antiox10030342
复制
发表时间：
2021-02-25
期刊：
影响因子：
--
通讯作者：
Erdman JW Jr
中科院分区：
文献类型：
--
作者：
Arballo J;Amengual J;Erdman JW Jr
番茄红素是一种非维生素原 A 类胡萝卜素，具有多种健康益处。流行病学数据支持番茄红素摄入量与多种慢性疾病（包括某些类型的癌症和心血管疾病）的减弱之间的相关性。目前尚不清楚这些有益作用是否来自番茄红素的天然结构或其代谢衍生物：番茄红素、番茄酚和番茄红素酸。本文综述重点介绍番茄红素消化、吸收、代谢和排泄方面的最新研究成果。本综述主要关注体内研究，因为在体外实验模型中研究类胡萝卜素具有不稳定的性质和困难。这些研究涉及番茄红素的组织积累、遗传和饮食因素导致的生物利用度的改变，以及β-胡萝卜素加氧酶 1 (BCO1) 和 β-胡萝卜素加氧酶 2 (BCO2) 酶对番茄红素的裂解。目前的文献表明，大多数番茄红素被 BCO2 偏心裂解，但还需要进一步研究来探测组织水平上的酶裂解活性。此外，结果表明单核苷酸多态性和膳食脂肪会影响番茄红素的吸收，从而改变其对健康的影响。需要进一步研究探索番茄红素的代谢、与其健康益处相关的机制以及提高生物利用度的最佳饮食组成。
Lycopene is a non-provitamin A carotenoid that exhibits several health benefits. Epidemiological data support a correlation between lycopene intake and the attenuation of several chronic diseases, including certain types of cancers and cardiovascular diseases. It is currently unknown whether the beneficial effects are from the native structure of lycopene or its metabolic derivatives: lycopenals, lycopenols, and lycopenoic acids. This literature review focuses on the current research on lycopene digestion, absorption, metabolism, and excretion. This review primarily focuses on in vivo studies because of the labile nature and difficulty of studying carotenoids within in vitro experimental models. The studies presented address tissue accumulation of lycopene, the modification of bioavailability due to genetic and dietary factors, and lycopene cleavage by the enzymes ß-carotene oxygenase 1 (BCO1) and ß-carotene oxygenase 2 (BCO2). The current literature suggests that the majority of lycopene is cleaved eccentrically by BCO2, yet further research is needed to probe the enzymatic cleavage activity at the tissue level. Additionally, results indicate that single nucleotide polymorphisms and dietary fat influence lycopene absorption and thus modify its health effects. Further research exploring the metabolism of lycopene, the mechanisms related to its health benefits, and optimal diet composition to increase the bioavailability is required.
登录
查看更多内容
影响因子：
4
作者：
Abar L;Vieira AR;Aune D;Stevens C;Vingeliene S;Navarro Rosenblatt DA;Chan D;Greenwood DC;Norat T
通讯作者：
Norat T
影响因子：
4.1
作者：
Cichon MJ;Moran NE;Riedl KM;Schwartz SJ;Clinton SK
通讯作者：
Clinton SK
影响因子：
4.2
作者：
Ford, Nikki A.;Clinton, Steven K.;Erdman, John W., Jr.
通讯作者：
Erdman, John W., Jr.
影响因子：
4.2
作者：
Boileau, AC;Merchen, NR;Erdman, JW
通讯作者：
Erdman, JW
影响因子：
4.8
作者：
Amengual, Jaume;Widjaja-Adhi, M. Airanthi K.;von Lintig, Johannes
通讯作者：
von Lintig, Johannes