Microbial pathogenesis and host defense in the nematode C. elegans.
Microbial pathogenesis and host defense in the nematode C. elegans.
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DOI：
10.1016/j.mib.2014.11.009
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发表时间：
2015-02
影响因子：
5.4
通讯作者：
Troemel ER
中科院分区：
文献类型：
--
作者：
Cohen LB;Troemel ER
Epithelial cells line the surfaces of the body, and are on the front lines of defense against microbial infection. Like many other metazoans, the nematode C. elegans lacks known professional immune cells and relies heavily on defense mediated by epithelial cells. New results indicate that epithelial defense in C. elegans can be triggered through detection of pathogen-induced perturbation of core physiology within host cells and through autophagic defense against intracellular and extracellular pathogens. Recent studies have also illuminated a diverse array of pathogenic attack strategies used against C. elegans. These findings are providing insight into the underpinnings of host/pathogen interactions in a simple animal host that can inform studies of infectious diseases in humans.
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影响因子：
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通讯作者：
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DOI：
10.1073/pnas.0914643107
发表时间：
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