Visual field profile of optic neuritis: a final follow-up report from the optic neuritis treatment trial from baseline through 15 years.
Visual field profile of optic neuritis: a final follow-up report from the optic neuritis treatment trial from baseline through 15 years.
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DOI：
10.1001/archophthalmol.2010.16
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发表时间：
2010-03
影响因子：
--
通讯作者：
Beck, Roy W.
中科院分区：
文献类型：
--
作者：
Keltner, John L.;Johnson, Chris A.;Cello, Kimberly E.;Dontchev, Mariya;Gal, Robin L.;Beck, Roy W.
目的：评估视神经炎治疗试验中一次视神经炎发作后的视野异常。三位读者独立评估了454名患者的10443个视野，并将视野异常分为21个不同的单眼类别，代表3种常见的视力损失类型：弥漫性、局限性和伪影。确定分类频率，并评估读者的一致性。评估视野异常分类与平均偏差、模式标准偏差、视力和中心凹阈值的关系。在基线时，弥漫性丢失占患眼异常的66.2%，而对侧眼仅占6.2%。从1岁到15岁，患眼和对侧眼主要表现为神经纤维束区域的局限性丢失(部分弓形、旁中心和弓形缺陷)。术后第1年，患眼和对侧眼的异常分别为35.7%和34.4%。在15岁时，39.5%的患眼和26.3%的对侧眼的异常包括局限性的缺陷。黄斑中心凹阈值与基线(−0.82vs0.79)、6个月(−0.84vs0.81)和1年(−0.84vs0.79)的视力和对比敏感度高度相关。基线时，患眼的弥漫性和中央性损害更为明显，而神经纤维束缺陷(部分弓形、旁中心和弓状)是研究期间患眼和对侧眼最常见的局部性异常。
To evaluate visual field abnormalities after an episode of optic neuritis among participants in the Optic Neuritis Treatment Trial. Three readers independently evaluated 10 443 visual fields from 454 patients and classified visual field abnormalities into 21 different monocular categories representing 3 general types of visual loss: diffuse, localized, and artifactual. Classification frequency was determined and reader agreement was evaluated. The association of visual field abnormality classifications with mean deviation, pattern standard deviation, visual acuity, and foveal threshold was assessed. At baseline, diffuse loss accounted for 66.2% of the abnormalities in the affected eyes but only 6.2% of the abnormalities in the fellow eyes. During years 1 through 15, the affected and fellow eyes exhibited predominantly localized loss in the nerve fiber bundle region (partial arcuate, paracentral, and arcuate defects). At year 1, 35.7% of the abnormalities in the affected eyes and 34.4% in the fellow eyes consisted of localized defects. At year 15, 39.5% of abnormalities in the affected eyes and 26.3% in the fellow eyes consisted of localized defects. Foveal threshold was highly correlated with visual acuity and contrast sensitivity in the affected eye at baseline (−0.82 vs 0.79, respectively), 6 months (−0.84 vs 0.81), and 1 year (−0.84 vs 0.79). Diffuse and central loss were more predominant in the affected eye at baseline, and nerve fiber bundle defects (partial arcuate, paracentral, and arcuate) were the most predominant localized abnormalities in both the affected and fellow eyes during the study.
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影响因子：
4.4
作者：
Gundogan, Fatih C.;Demirkaya, Seref;Sobaci, Gungor
通讯作者：
Sobaci, Gungor
影响因子：
11.2
作者：
Trip, SA;Schlottmann, PG;Miller, DH
通讯作者：
Miller, DH
影响因子：
13.7
作者：
Keltner, John L.;Johnson, Chris A.;Hypertension, Ocular
通讯作者：
Hypertension, Ocular
影响因子：
--
作者：
KELTNER, JL;JOHNSON, CA;BECK, RW
通讯作者：
BECK, RW
DOI：
10.1007/s00417-007-0722-2
发表时间：
2008-04-01
影响因子：
2.7
作者：
Nevalainen, J.;Krapp, E.;Schiefer, U.
通讯作者：
Schiefer, U.