Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
Epstein-Barr virus-positive T/NK-cell lymphoproliferative disorders.
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DOI：
10.1038/emm.2014.105
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发表时间：
2015-01-23
影响因子：
12.8
通讯作者：
Young, Ken H.
中科院分区：
文献类型：
--
作者：
Cai, Qingqing;Chen, Kailin;Young, Ken H.
爱泼斯坦-巴尔病毒是一种普遍存在的人类疱疹病毒，可以诱导溶解性和潜伏性感染，从而导致多种人类疾病，包括淋巴组织增生性疾病。EB病毒的致癌潜力与其感染B淋巴细胞并将其转化为持续增殖的淋巴母细胞样细胞的能力有关。然而，EB病毒也与T/自然杀伤细胞淋巴增生性疾病的发展有关。Epstein-Barr病毒编码一系列模拟几种生长、转录和抗凋亡因子的产物，从而篡夺调节多种稳态细胞功能和微环境的途径的控制。然而，EB病毒促进肿瘤发生和炎性病变发展的确切机制仍不清楚。EB病毒相关T/自然杀伤细胞淋巴增生性疾病通常具有重叠的临床症状以及组织学和免疫表型特征，因为两种淋巴细胞类型均源自共同的前体。EB病毒相关T/自然杀伤细胞淋巴增殖性疾病的准确分类是适当的临床管理的先决条件。目前，大多数T/自然杀伤细胞淋巴增殖性疾病的治疗不太令人满意。迫切需要新的靶向治疗来满足临床需求。本文就EB病毒相关性T/自然杀伤细胞淋巴增殖性疾病的遗传学、肿瘤发生、生物学、诊断和治疗等方面的研究进展作一综述。
Epstein–Barr virus, a ubiquitous human herpesvirus, can induce both lytic and latent infections that result in a variety of human diseases, including lymphoproliferative disorders. The oncogenic potential of Epstein–Barr virus is related to its ability to infect and transform B lymphocytes into continuously proliferating lymphoblastoid cells. However, Epstein–Barr virus has also been implicated in the development of T/natural killer cell lymphoproliferative diseases. Epstein–Barr virus encodes a series of products that mimic several growth, transcription and anti-apoptotic factors, thus usurping control of pathways that regulate diverse homeostatic cellular functions and the microenvironment. However, the exact mechanism by which Epstein–Barr virus promotes oncogenesis and inflammatory lesion development remains unclear. Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases often have overlapping clinical symptoms as well as histologic and immunophenotypic features because both lymphoid cell types derive from a common precursor. Accurate classification of Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases is a prerequisite for appropriate clinical management. Currently, the treatment of most T/natural killer cell lymphoproliferative diseases is less than satisfactory. Novel and targeted therapies are strongly required to satisfy clinical demands. This review describes our current knowledge of the genetics, oncogenesis, biology, diagnosis and treatment of Epstein–Barr virus-associated T/natural killer cell lymphoproliferative diseases.
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