Sensory experience restructures thalamocortical axons during adulthood.
Sensory experience restructures thalamocortical axons during adulthood.
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DOI：
10.1016/j.neuron.2012.03.022
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发表时间：
2012-05-24
期刊：
影响因子：
16.2
通讯作者：
Bruno RM
中科院分区：
文献类型：
--
作者：
Oberlaender M;Ramirez A;Bruno RM
人们认为大脑的重新连接能力会随着年龄的增长而减弱。人们普遍认为，发育稳定了从丘脑到皮层的突触，而成年人的经历只改变了皮层神经元之间的突触连接。在这里，我们表明，丘脑皮质（TC）输入本身经历了巨大的可塑性在成年人。我们结合全细胞记录从个别丘脑皮质神经元在成年大鼠最近开发的自动跟踪技术，以重建个人轴突树。胡须修剪大大减少了桶皮质的丘脑皮质轴突长度，但不是TC突触的密度沿着纤维。因此，感觉经验改变了TC突触的总数。修剪后，感觉刺激引起更紧密的时间锁定的反应之间的丘脑感受器层4皮层神经元。这些发现表明，丘脑皮质的输入本身在成年后仍然具有可塑性，这增加了其他皮质下结构的轴突在整个生命过程中也可能保持流动的可能性。
The brain’s capacity to rewire is thought to diminish with age. It is widely believed that development stabilizes the synapses from thalamus to cortex and that adult experience alters only synaptic connections between cortical neurons. Here we show that thalamocortical (TC) inputs themselves undergo massive plasticity in adults. We combined whole-cell recording from individual thalamocortical neurons in adult rats with a recently developed automatic tracing technique to reconstruct individual axonal trees. Whisker trimming substantially reduced thalamocortical axon length in barrel cortex but not the density of TC synapses along a fiber. Thus, sensory experience alters the total number of TC synapses. After trimming, sensory stimulation evoked more tightly time-locked responses among thalamorecipient layer 4 cortical neurons. These findings indicate that thalamocortical input itself remains plastic in adulthood, raising the possibility that the axons of other subcortical structures might also remain in flux throughout life.
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